Evidence map›Paper›PMID 27565301›Full record

ArticleNeurobiology of aging2016

White matter integrity as a marker for cognitive plasticity in aging.

Ann-Marie Glasø de Lange, Anne Cecilie Sjøli Bråthen, Håkon Grydeland, Claire Sexton, Heidi Johansen-Berg, Jesper L R Andersson, Darius A Rohani, Lars Nyberg, Anders M Fjell, Kristine B Walhovd

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Ann-Marie Glasø de LangeResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway. Electronic address: a.m.g.d.lange@psykologi.uio.no.
Anne Cecilie Sjøli BråthenResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Håkon GrydelandResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Claire SextonOxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Heidi Johansen-BergOxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jesper L R AnderssonOxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Darius A RohaniResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Lars NybergUmeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Anders M FjellResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Physical Medicine and Rehabilitation, Unit of Neuropsychology, Oslo University Hospital, Oslo, Norway.
Kristine B WalhovdResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Physical Medicine and Rehabilitation, Unit of Neuropsychology, Oslo University Hospital, Oslo, Norway.
University of Oslo · NOUniversity of Oxford · GBOslo University Hospital · NOUmeå University · SE

Funding

Wellcome Trust
6 · The paper itself

Abstract

Age-related differences in white matter (WM) integrity are substantial, but it is unknown whether between-subject variability in WM integrity influences the capacity for cognitive improvement. We investigated the effects of memory training related to active and passive control conditions in older adults and tested whether WM integrity at baseline was predictive of training benefits. We hypothesized that (1) memory improvement would be restricted to the training group, (2) widespread areas would show greater mean diffusivity (MD) and lower fractional anisotropy in older adults relative to young adults, and (3) within these areas, variability in WM microstructure in the older group would be predictive of training gains. The results showed that only the group receiving training improved their memory. Significant age differences in MD and fractional anisotropy were found in widespread areas. Within these areas, voxelwise analyses showed a negative relationship between MD and memory improvement in 3 clusters, indicating that WM integrity could serve as a marker for the ability to adapt in response to cognitive challenges in aging.

Indexed as

AdultAgedAged, 80 and overAgingAnisotropyBiomarkersCognitionDiffusion Tensor ImagingFemaleHumansMaleMemoryNeuronal PlasticityWhite MatterYoung AdultBiomarkersAgingCognitive trainingDiffusion tensor imagingMemoryPlasticityWhite matter

Identifiers

PMID27565301
PMCPMC5404118
OpenAlexW2477020078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.