Evidence map›Paper›PMID 27565163›Full record

ArticleClinical & experimental metastasis2016

Expression of natural killer cell regulatory microRNA by uveal melanoma cancer stem cells.

Powrnima Joshi, Mitra Kooshki, Wayne Aldrich, Daniel Varghai, Maciej Zborowski, Arun D Singh, Pierre L Triozzi

Open access · greenAbstract read
In one paragraph

Article in Clinical & experimental metastasis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. The Roles of MiRNAs (MicroRNAs) in Melanoma Immunotherapy.International journal of molecular sciences · 2022
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Emerging roles of microRNAs and their implications in uveal melanoma.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. A Review of MicroRNA in Uveal Melanoma.OncoTargets and therapy · 2020
    Review
  15. Review
  16. Review
  17. Liquid Biopsy and Ocular Tumors: A Review.Journal of current ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Powrnima JoshiLerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Mitra KooshkiComprehensive Cancer Center, Wake Forest University, Winston-Salem, NC, 27157, USA.
Wayne AldrichTaussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Daniel VarghaiLerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Maciej ZborowskiLerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Arun D SinghCole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Pierre L TriozziComprehensive Cancer Center, Wake Forest University, Winston-Salem, NC, 27157, USA. ptriozzi@wakehealth.edu.ORCID 0000-0003-2488-6136
Cleveland Clinic · USWake Forest University · US

Funding

Magnetophoretic Cell Sorting and AnalysisR01CA062349 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZBOROWSKI, MACIEJ · 1994 to 2015
$5.5M
Differentiation Therapy of Uveal Melanoma MicrometastasesR21CA175671 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TRIOZZI, PIERRE L · 2014 to 2015
$379k
NCI NIH HHS R01 CA062349NCI NIH HHS R21 CA175671
6 · The paper itself

Abstract

Natural killer (NK) cells are implicated in the control of metastasis in uveal melanoma, a process that has been ascribed to its cancer stem cell subpopulation. NK cell activation is regulated by specific microRNA (miR). The NK cell sensitivity and regulatory miR production of uveal melanoma cancer stem cells was examined. Cancer stem cells enriched from aggressively metastatic MUM2B uveal melanoma cells by selecting CD271

Indexed as

AdapaleneCytotoxicity, ImmunologicGene Expression Regulation, NeoplasticHumansKiller Cells, NaturalMelanocytesMelanomaMicroRNAsNeoplastic Stem CellsTransfectionUveal MelanomaUveal NeoplasmsAdapaleneMicroRNAsMIRN155 microRNA, humanCD271Major histocompatibility complex class I moleculesMelanospheresMHC class I-related chain AMicrophthalmia-associated transcription factormiR-155

Identifiers

PMID27565163
PMCPMC9082981
OpenAlexW2517480427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.