ArticleThe Journal of surgical research2016
Operation with less adjuvant therapy for elderly breast cancer.
Article in The Journal of surgical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Integrated insights into gut microbiota and metabolomic landscape in breast cancer patients undergoing adjuvant endocrine therapy.mSystems · 2025Article
- Article
- Survival Outcome and Predictors of Survival in Elderly Breast Cancer Patients following Curative Treatment.South Asian journal of cancer · 2023Article
- Triple-negative and Her2-positive breast cancer in women aged 70 and over: prognostic impact of age according to treatment.Frontiers in oncology · 2023Article
- Article
- Older breast cancer undertreatment: unconscious bias to undertreat-potential role for the international geriatric radiotherapy group?Translational cancer research · 2020Review
- Prevention of locoregional recurrence and distant metastasis in Japanese breast cancer patients using Japanese standard postoperative radiation fields: Experience at a single institution.Cancer reports (Hoboken, N.J.) · 2019Article
- Correlations ofBioscience reports · 2018Article
- Treatment Strategies in Elderly Patients With Operable, Hormone Receptor-negative Breast Cancer.Cancer diagnosis & prognosisArticle
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe standard of care for elderly women with breast cancer remains controversial. The aim of this study was to clarify the management of elderly breast cancer patients who undergo surgery. MATERIALS AND
methodsThis retrospective single-center cohort study included 2276 breast cancer patients who underwent surgery between 1993 and 2014. The patients were divided into three groups according to age: ≤64 y (young), 65-74 y (older), and ≥75 y (elderly).
resultsThe elderly had more advanced stage disease at diagnosis (stage III and IV, 16.2%, 17.5%, and 22.1% for the young, older, and elderly groups, respectively). The elderly were more likely to undergo mastectomy (43.3%, 41.4%, and 50.7%, respectively), omit axillary operation (0.6%, 1.1%, and 9.3%, respectively), and skip radiotherapy after breast-conserving surgery (93.1%, 86.8%, and 29.1%, respectively). Endocrine therapy was widely used in all the groups (94.4%, 93.8%, and 90.1%, respectively), but frequency of chemotherapy was lower in the elderly regardless of hormone receptor (HR) status (40.8%, 25.5%, and 9.3% in HR(+), 87.2%, 75.3%, and 39.5% in HR(-), respectively). Although the locoregional recurrence rate was higher in the elderly (4.2%, 3.4%, and 7.0% at 5 y, respectively; P = 0.028), there were no differences among groups in distant metastasis-free survival or breast cancer-specific survival.
conclusionsAlthough elderly patients had more advanced stages of cancer and received less treatment, there were no differences in survival. Omission of axillary dissection, radiation, and chemotherapy after operation may be an option for breast cancer patients aged ≥75 y.
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