ArticleThe European journal of neuroscience2016
Relative contribution of the dorsal raphe nucleus and ventrolateral periaqueductal gray to morphine antinociception and tolerance in the rat.
Article in The European journal of neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Dorsal raphe nucleus enkephalin peptide modulates behavioral preference.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Shuyu capsule improves estrous cycle-dependent depression-like behavior in premenstrual dysphoric disorder (PMDD) mice by increasing GABAergic neuronal activation and downregulating GABAJournal of Zhejiang University. Science. B · 2025Article
- Narrative review of the scientific and methodological explanations for 101 mechanisms of opioid tolerance.Pain reports · 2025Article
- Convergent state-control of endogenous opioid analgesia.bioRxiv : the preprint server for biology · 2025Article
- Divergent modulation of pain and anxiety by GABAergic neurons in the ventrolateral periaqueductal gray and dorsal raphe.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Cannabigerol modulates αFrontiers in pharmacology · 2023Article
- Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors.Cellular and molecular neurobiology · 2022Article
- Functional characterization of cannabidiol effect on the serotonergic neurons of the dorsal raphe nucleus in rat brain slices.Frontiers in pharmacology · 2022Article
- 3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects.Science advances · 2021Article
- Article
- Evidence and explanation for the involvement of the nucleus accumbens in pain processing.Neural regeneration research · 2020Review
- The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance.Frontiers in neuroscience · 2018Article
- A neuroanatomical framework for the central modulation of respiratory sensory processing and cough by the periaqueductal grey.Journal of thoracic disease · 2017Review
- Article
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3 authors.
Funding
Abstract
The dorsal raphe nucleus (DRN) is embedded in the ventral part of the caudal periaqueductal gray (PAG). Electrical or chemical activation of neurons throughout this region produces antinociception. The objective of this manuscript is to determine whether the ventrolateral PAG and DRN are distinct antinociceptive systems. This hypothesis was tested by determining the antinociceptive potency of microinjecting morphine into each structure (Experiment 1), creating a map of effective microinjection sites that produce antinociception (Experiment 2) and comparing the development of antinociceptive tolerance to repeated microinjections of morphine into the ventrolateral PAG and DRN (Experiment 3). Morphine was more potent following cumulative injections (1.0, 2.2, 4.6 & 10 μg/0.2 μL) into the ventrolateral PAG (D
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