ArticleeLife2016
Seipin is required for converting nascent to mature lipid droplets.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 237 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 1 pooled it
27.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
237 citing papers in PubMed, 1 synthesis or guideline pooled it, 393 citations in OpenAlex.
- Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024Pooled it
- Mitochondria-endoplasmic reticulum-lipid droplet crosstalk in lipid metabolic reprogramming in type 2 diabetes mellitus.Journal of lipid research · 2026Review
- Tripartite ER-mitochondria-lipid droplets contact sites control adipocyte metabolic flexibility.The EMBO journal · 2026Article
- Single-Cell Transcriptomics Reveals the FA9-VAP Module Regulating Fatty Acid Accumulation in Soybean Seeds.Plant biotechnology journal · 2026Article
- Lipid droplets promote aberrant liquid-liquid phase separation of alpha-synuclein impairing energy homeostasis.EMBO reports · 2026Article
- Opposing roles of DGAT-mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity.The FEBS journal · 2026Article
- Lipid droplet size profiling in yeast.Biology open · 2026Article
- Optical photothermal infrared imaging of fatty acid esterification in the ER of living cells.Science advances · 2026Article
- Activity-dependent lipid droplet biogenesis and turnover regulate synaptic integrity.bioRxiv : the preprint server for biology · 2026Article
- Article
- Lipid droplet proteome plasticity in plant evolution, growth and development, and response to stress.Journal of experimental botany · 2026Review
- Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets.Nature cell biology · 2026Article
- Hairpin herds corralled at the lipid droplet.Nature cell biology · 2026Article
- Heterogeneity, dynamics and organelle interactions of lipid droplets.Nature reviews. Molecular cell biology · 2026Review
- Seipin-defined ER sites undergo distinct enrichment of factors for the biogenesis of sterol ester rich lipid droplets.iScience · 2026Article
- Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review).International journal of molecular medicine · 2026Review
- Optical photothermal infrared imaging of fatty acid esterification in the ER of living cells.bioRxiv : the preprint server for biology · 2026Article
- BnaC03.SEIPIN1 improves seed oil content by increasing the number of lipid droplets in Brassica napus.BMC plant biology · 2026Article
- Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis.Journal of lipid research · 2026Article
- Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy.The FEBS journal · 2026Article
177 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 9 institutions in 5 countries.
Huajin WangDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, United States.
Michel BecuweDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.
Benjamin E HousdenDepartment of Genetics, Harvard Medical School, Boston, United States.
Chandramohan ChitrajuDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.
Ashley J PorrasDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.
Morven M GrahamCenter for Cellular and Molecular Imaging, Department of Cell Biology, Yale School of Medicine, New Haven, United States.
Xinran N LiuCenter for Cellular and Molecular Imaging, Department of Cell Biology, Yale School of Medicine, New Haven, United States.
Abdou Rachid ThiamLaboratoire de Physique Statistique, École Normale Supérieure, PSL Research University, Université Paris Diderot Sorbonne Paris-Cité, Sorbonne Universités UPMC Univ Paris 06, CNRS UMR 8550, Paris, France.
David B SavageThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.
Anil K AgarwalDivision of Nutrition and Metabolic Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, United States.
Abhimanyu GargDivision of Nutrition and Metabolic Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, United States.
Maria-Jesus OlarteDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.
Qingqing LinDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.
Florian FröhlichDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.
Hans Kristian Hannibal-BachVILLUM Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Srigokul UpadhyayulaDepartment of Cell Biology, Harvard Medical School, Boston, United States.
Norbert PerrimonDepartment of Genetics, Harvard Medical School, Boston, United States.
Tomas KirchhausenDepartment of Cell Biology, Harvard Medical School, Boston, United States.
Christer S EjsingVILLUM Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Tobias C WaltherDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.
Robert V FareseDepartment of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.ORCID http://orcid.org/0000-0001-8103-2239
Boston University · USBroad Institute · USSouthwestern Medical Center · USUniversity of Southern Denmark · DKYale University · USCentre National de la Recherche Scientifique · FRHarvard University · USHoward Hughes Medical Institute · USUniversity of Cambridge · GB
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNew collections of dsRNAs and overexpression miRNA constructs to supplement RNAiR01GM067761 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI PERRIMON, NORBERT · 2003 to 2019
$15.5MDynamics of Clathrin Coat Formation in CellsR01GM075252 · NIGMS · IMMUNE DISEASE INSTITUTE, INC. · PI KIRCHHAUSEN, TOMAS · 2005 to 2018
$4.6MNIGMS NIH HHS R01 GM067761
Abstract
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using
Indexed as
cell biologyD. melanogasterendoplasmic reticulumhumanlipid dropletlipid metabolismLiveDroporganelle biogenesisseipin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.