ReviewJournal of neurosurgical anesthesiology2016
Molecular Mechanisms of Anesthetic Neurotoxicity: A Review of the Current Literature.
Review in Journal of neurosurgical anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Anesthetic neurotoxicity in the developing brain: an update on theinsights and implications for fetal surgery.Anesthesia and pain medicine · 2024Article
- Early Postnatal Exposure to Midazolam Causes Lasting Histological and Neurobehavioral Deficits via Activation of the mTOR Pathway.International journal of molecular sciences · 2024Article
- In-vivo and in-vitro toxicity evaluation of 2,3-dimethylquinoxaline: An antimicrobial found in a traditional herbal medicine.PloS one · 2024Article
- The effects of general anesthetics on mitochondrial structure and function in the developing brain.Frontiers in neurology · 2023Review
- Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol.Frontiers in aging neuroscience · 2023Article
- Early Isoflurane Exposure Impairs Synaptic Development in Fmr1 KO Mice via the mTOR Pathway.Neurochemical research · 2021Article
- GABAergic neurons are susceptible to BAX-dependent apoptosis following isoflurane exposure in the neonatal period.PloS one · 2021Article
- Genistein Attenuates Isoflurane-Induced Neuroinflammation by Inhibiting TLR4-Mediated Microglial-Polarization in vivo and in vitro.Journal of inflammation research · 2021Article
- Role of Unfolded Protein Response and Endoplasmic Reticulum-Associated Degradation by Repeated Exposure to Inhalation Anesthetics inInternational journal of medical sciences · 2021Article
- Effects of Early Exposure of Isoflurane on Chronic Pain via the Mammalian Target of Rapamycin Signal Pathway.International journal of molecular sciences · 2019Article
- Nitric Oxide Donor Prevents Neonatal Isoflurane-induced Impairments in Synaptic Plasticity and Memory.Anesthesiology · 2019Article
- Neurotoxicity of Anesthesia in Children: Prevention and Treatment.Current treatment options in neurology · 2018Review
- Anesthetics disrupt brain development via actions on the mTOR pathway.Communicative & integrative biology · 2018Article
- Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination.Journal of anesthesia · 2017Article
- Anesthetics disrupt growth cone guidance cue sensing through actions on the GABANeurotoxicology and teratologyArticle
- Anesthetic neurotoxicity: Apoptosis and autophagic cell death mediated by calcium dysregulation.Neurotoxicology and teratologyReview
- Neurogenesis and developmental anesthetic neurotoxicity.Neurotoxicology and teratologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Data from epidemiologic studies and animal models have raised a concern that exposure to anesthetic agents during early postnatal life may cause lasting impairments in cognitive function. It is hypothesized that this is due to disruptions in brain development, but the mechanism underlying this toxic effect remains unknown. Ongoing research, particularly in rodents, has begun to address this question. In this review we examine currently postulated molecular mechanisms of anesthetic toxicity in the developing brain, including effects on cell death pathways, growth factor signaling systems, NMDA and GABA receptors, mitochondria, and epigenetic factors. The level of evidence for each putative mechanism is critically evaluated, and we attempt to draw connections between them where it is possible to do so. Although there are many promising avenues of research, at this time no consensus can be reached as to a definitive mechanism of injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.