Evidence map›Paper›PMID 27564547›Full record

ArticleAmerican journal of respiratory cell and molecular biology2017

Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4

Lindsay J Celada, Joseph E Rotsinger, Anjuli Young, Guzel Shaginurova, Debresha Shelton, Charlene Hawkins, Wonder P Drake

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Immunopathogenesis of Sarcoidosis.Seminars in respiratory and critical care medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lindsay J Celada1 Division of Infectious Diseases, Department of Medicine, and.
Joseph E Rotsinger1 Division of Infectious Diseases, Department of Medicine, and.
Anjuli Young1 Division of Infectious Diseases, Department of Medicine, and.
Guzel Shaginurova2 Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Debresha Shelton1 Division of Infectious Diseases, Department of Medicine, and.
Charlene Hawkins1 Division of Infectious Diseases, Department of Medicine, and.
Wonder P Drake1 Division of Infectious Diseases, Department of Medicine, and.
Office of Infectious Diseases · USVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Immunobiology of Blood and Vascular Systems Training ProgramT32HL069765 · NHLBI · VANDERBILT UNIVERSITY · PI HAWIGER, JACK J · 2002 to 2016
$6.5M
Interdisciplinary Training Program in Lung ResearchT32HL094296 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ray Stokes Peebles · 2008 to 2026
$6.3M
Microbial induction of sarcoidosis CD4+ T cell dysfunctionR01HL117074 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL, DRAKE, WONDER P. · 2013 to 2017
$3.8M
Investigation of the role of bacteria in the sarcoidosis trimolecular complexR01HL083839 · NHLBI · VANDERBILT UNIVERSITY · PI DRAKE, WONDER P. · 2006 to 2009
$1.5M
Mentoring in Translational Research in Interstitial Lung DiseasesK24HL127301 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wonder P. Drake · 2016 to 2026
$1.2M
Investigation of microbial hetergeneity to sarcoidosis and AAT clinical outcomeU01HL112694 · NHLBI · VANDERBILT UNIVERSITY · PI DRAKE, WONDER P. · 2012 to 2014
$463k
NCI NIH HHS P30 CA068485NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K24 HL127301NHLBI NIH HHS R01 HL083839NHLBI NIH HHS R01 HL117074NHLBI NIH HHS T32 HL069765NHLBI NIH HHS T32 HL094296NHLBI NIH HHS U01 HL112694NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Patients with progressive sarcoidosis exhibit increased expression of programmed death-1 (PD-1) receptor on their CD4

Indexed as

Signal TransductionAdultAgedCase-Control StudiesCD4-Positive T-LymphocytesCell ProliferationDemographyFemaleGene Expression RegulationHumansMaleMiddle AgedPhosphatidylinositol 3-KinaseProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-aktSarcoidosisPDCD1 protein, humanPhosphatidylinositol 3-KinaseProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAKTlymphocyte cell-specific protein-tyrosine kinasephosphatidylinositol 3-kinaseprogrammed death-1proliferationsarcoidosis

Identifiers

PMID27564547
PMCPMC5248958
OpenAlexW2512540362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.