Evidence map›Paper›PMID 27564524›Full record

ArticleNutrition and cancer2016

Increased Risk of Nasopharyngeal Carcinoma with Increasing Levels of Diet-Associated Inflammation in an Italian Case-Control Study.

Nitin Shivappa, James R Hébert, Antonella Zucchetto, Maurizio Montella, Massimo Libra, Werner Garavello, Marta Rossi, Carlo La Vecchia, Diego Serraino

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  16. Ageing: from inflammation to cancer.Immunity & ageing : I & A · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Nitin Shivappaa South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.
James R Héberta South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.
Antonella Zucchettod Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute , Aviano , Italy.
Maurizio Montellae Department of Epidemiology , 'Fondazione G. Pascale', Istituto Nazionale Tumori , Naples , Italy.
Massimo Libraf Department of Biomedical and Biotechnological Sciences , University of Catania , Catania , Italy.
Werner Garavellog Department of Surgery and Translational Medicine , University of Milano-Bicocca , Milan , Italy.
Marta Rossih Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy.
Carlo La Vecchiah Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy.
Diego Serrainod Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute , Aviano , Italy.
Centro di Riferimento Oncologico · ITUniversity of Milan · ITConnecting Health Innovations (United States) · USIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Catania · ITUniversity of Milano-Bicocca · ITUniversity of South Carolina · US

Funding

Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
NIDDK NIH HHS R44 DK103377
6 · The paper itself

Abstract

purposeComponents of diet can modulate inflammation and therefore may have an important role in the development of nasopharyngeal carcinoma (NPC). Little is known about the inflammatory potential of diet in relation to nasopharyngeal carcinogenesis.

methodsData from an Italian multicenter case-control study conducted between 1992 and 2008 and including 198 cases with incident, histologically confirmed NPC, and 594 controls hospitalized for acute nonneoplastic diseases were used to estimate the relation between a dietary inflammatory index (DII) and the risk of NPC. The DII was computed based on the intake of selected dietary factors assessed by a validated 78-item food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) adjusted for study center, place of living, sex, age, year of interview, education, tobacco smoking, alcohol drinking, and energy intake using the residual method.

resultsSubjects with higher DII scores had an increased risk of NPC, with each DII point increasing risk by nearly 20% [OR: 1.19; 95% confidence interval (CI): 1.05-1.36]. Compared to subjects in the lowest DII tertile, those in the highest tertile had >60% higher risk of NPC (OR: 1.64; 95% CI: 1.06-2.55; Ptrend = 0.04).

conclusionThese results indicate that inflammatory potential of diet plays a role in NPC.

Indexed as

AdolescentAdultAgedBiomarkers, TumorCarcinomaCase-Control StudiesDiet, Carbohydrate LoadingDiet, High-FatFemaleHospitals, GeneralHospitals, TeachingHumansIncidenceInflammation MediatorsItalyMaleBiomarkers, TumorInflammation Mediators

Identifiers

PMID27564524
PMCPMC5051264
OpenAlexW2509285948

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.