Evidence map›Paper›PMID 27564515›Full record

Observational studyOptometry and vision science : official publication of the American Academy of Optometry2016

Internal Astigmatism in Myopes and Non-myopes: Compensation or Constant?

Ruth E Manny, Li Deng, Jane Gwiazda, Leslie Hyman, Erik Weissberg, Mitchell Scheiman, Karen D Fern, COMET Study Group

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Optometry and vision science : official publication of the American Academy of Optometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Astigmatism Types Effects on Internal Astigmatism and Compensation in Children: Hong Kong Children Eye Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  2. Body Mass Index is Associated With Direction-Specific Increases in With-the-Rule Corneal and Refractive Astigmatism in Schoolchildren.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ruth E Manny*OD, PhD, FAAO†PhD, FAAO‡OD, FAAOUniversity of Houston College of Optometry, Houston, Texas (REM, KDF); New England College of Optometry, Boston, Massachusetts (LD, JG, EW); Department of Preventive Medicine, Stony Brook University Health Sciences Center, Stony Brook, New York (LH); and Pennsylvania College of Optometry at Salus University, Philadelphia, Pennsylvania (MS).
Li Deng
Jane Gwiazda
Leslie Hyman
Erik Weissberg
Mitchell Scheiman
Karen D Fern
COMET Study Group
New England College of Optometry · USSalus University · USUniversity of Houston · USStony Brook Medicine · US

Funding

EVALUATION TRIAL--COORDINATING CENTERU10EY011805 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HYMAN, LESLIE G · 1996 to 2013
$9.4M
CORRECTION OF MYOPIA EVALUATION TRIAL--CLINICAL CENTERU10EY011754 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEISE, KATHERINE K · 1997 to 2013
$2.9M
CORRECTION OF MYOPIA TRIAL--CLINICAL CENTERU10EY011740 · NEI · UNIVERSITY OF HOUSTON · PI MANNY, RUTH E · 1997 to 2013
$2.8M
CORRECTION OF MYOPIA EVALUATION TRIAL (COMET)U10EY011755 · NEI · SALUS UNIVERSITY · PI SCHEIMAN, MITCHELL M · 1997 to 2013
$2.6M
CORRECTION OF MYOPIA EVALUATION TRIAL--CLINICAL CENTERU10EY011752 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI WEISSBERG, ERIK MATTHEW · 1997 to 2012
$2.3M
CORRECTION OF MYOPIA EVALUATION TRIAL--CHAIR PHASE IIU10EY011756 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI GWIAZDA, JANE E. · 1997 to 2013
$2.1M
Changes in astigmatism and anisometropia with progressing myopia in COMETR21EY023263 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI GWIAZDA, JANE E. · 2013 to 2013
$202k
NEI NIH HHS R21 EY023263NEI NIH HHS U10 EY011740NEI NIH HHS U10 EY011752NEI NIH HHS U10 EY011754NEI NIH HHS U10 EY011755NEI NIH HHS U10 EY011756NEI NIH HHS U10 EY011805
6 · The paper itself

Abstract

purposeTo examine internal astigmatism (IA) in myopes and non-myopes using a new method to assess compensation of corneal astigmatism (CA) by IA, to look for predictors of high IA in young adult myopes, and to determine if as CA changes IA changes to reduce refractive astigmatism (RA) in an active compensatory process in myopes.

methodsRight eye keratometry and cycloplegic autorefraction were measured annually over 14 years in 367 myopes and once in 204 non-myopes age- (mean 21.91 ± 1.47 years), gender-, and ethnicity-matched to myopes at year 12. CA and RA at the corneal plane were expressed as J0, J45. IA = RA - CA. Inverse power transformation provided cylinder power and axis of IA for the compensation factor (IA/CA). Analyses included (1) paired and unpaired t-tests (refractive data), (2) chi-square tests (distributions of compensation factor), (3) logistic regression analysis (predictors of high IA), and (4) linear mixed models (time effect on RA, CA, and IA).

resultsThe magnitude of IAJ0 varied by refractive error (myopes -0.25 ± 0.24 vs. non-myopes -0.32 ± 0.21, p < 0.001). Compensation of CA by IA was poorer in myopes than non-myopes (χ p < 0.001). When matched by CA, compensation remained poorer in myopes than non-myopes (χ all p ≤ 0.04). Within each refractive group, compensation was better when CA was low than high (χ p < 0.001). When CA was low in myopes, high IA (≥1.00D) was less likely (p = 0.01). Longitudinal follow-up of myopes found no evidence for an active compensatory role for IA as CA increased over time. There were differences in IAJ0 by ethnicity over time (p < 0.0001).

conclusionsIn myopic and non-myopic eyes with low amounts of CA, IA may reduce CA's contribution to RA, but IA is not a constant. However, there is no evidence for an active compensatory role for IA reducing CA in myopes.

Indexed as

EthnicityForecastingAdolescentAdultAstigmatismChildCorneaDisease ProgressionFemaleHumansIncidenceMaleMyopiaRefraction, OcularUnited StatesVision Tests

Identifiers

PMID27564515
PMCPMC5003335
OpenAlexW2511127938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.