ArticleAmerican journal of respiratory and critical care medicine2017
Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers.
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49citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
Who cites it
49 citing papers in PubMed, 78 citations in OpenAlex.
- Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy.Annals of the American Thoracic Society · 2019Trial
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- Genetic resilience to chronic obstructive pulmonary disease is a clinically distinct subtype in individuals with cigarette smoke exposure.Respiratory research · 2025Article
- Interrelationship Between Obstructive Sleep Apnea Syndrome and Small Airway Disease: A Comprehensive Review.Biomedicines · 2025Review
- Bronchodilator responsiveness and future chronic airflow obstruction: a multinational longitudinal study.EClinicalMedicine · 2025Article
- Age-related lung structure changes by quantitative assessment: a cross-sectional study in a Chinese male cohort.Frontiers in aging · 2025Article
- The chronological age at which small airway function starts to decline in a healthy Chinese population: a cross-sectional study.Frontiers in allergy · 2025Article
- The Impact of Age and Disease Entity on Small Airway Dysfunction in Obstructive Airway Diseases.International journal of chronic obstructive pulmonary disease · 2025Article
- Causal association between cigarette smoking and the prevalence of preserved ratio impaired spirometry (PRISm), and the progression risk factors of PRISm: A study based on Mendelian randomization and meta-analysis.Tobacco induced diseases · 2025Article
- Discordant definitions of small airway dysfunction between spirometry and parametric response mapping: the HRCT-based study.Insights into imaging · 2024Article
- Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population.Toxics · 2024Article
- Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry.American journal of respiratory and critical care medicine · 2024Article
- Development of machine learning model to predict pulmonary function with low-dose CT-derived parameter response mapping in a community-based chest screening cohort.Journal of applied clinical medical physics · 2023Article
- The utility of quantitative computed tomography in cohort studies of chronic obstructive pulmonary disease: a narrative review.Journal of thoracic disease · 2023Review
- Childhood to adulthood: Accounting for age dependence in healthy-reference distributions inMagnetic resonance in medicine · 2023Article
- Human Immunodeficiency Virus-associated Chronic Obstructive Pulmonary Disease Is Characterized by Increased Small Airways Dysfunction on Computed Tomography Imaging.Annals of the American Thoracic Society · 2023Article
- The association between small airway dysfunction and aging: a cross-sectional analysis from the ECOPD cohort.Respiratory research · 2022Article
- Association between age, gender, body mass index, and pulmonary function in preoperative patients with lung cancer.The clinical respiratory journal · 2022Observational
- Development and Evaluation of a Small Airway Disease Index Derived From Modeling the Late-Expiratory Flattening of the Flow-Volume Loop.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
22 authors at 12 institutions in 1 country.
Carlos H Martinez1 Division of Pulmonary and Critical Care Medicine.
Alejandro A Diaz2 Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Catherine Meldrum1 Division of Pulmonary and Critical Care Medicine.
Jeffrey L Curtis1 Division of Pulmonary and Critical Care Medicine.
Christopher B Cooper4 Division of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, California.
Cheryl Pirozzi5 Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, Utah.
Richard E Kanner5 Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, Utah.
Robert Paine5 Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, Utah.
Prescott G Woodruff7 Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California.
Eugene R Bleecker8 Division of Pulmonary and Critical Care Medicine, Wake Forest University, Winston-Salem, North Carolina.
Nadia N Hansel9 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
R Graham Barr10 Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, New York.
Nathaniel Marchetti11 Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania.
Gerard J Criner11 Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania.
Ella A Kazerooni12 Department of Radiology, and.
Eric A Hoffman13 Department of Radiology and Biomedical Engineering, University of Iowa, Iowa City, Iowa; and.
Brian D Ross12 Department of Radiology, and.
Craig J Galban12 Department of Radiology, and.
Christine T Cigolle16 Geriatric Research and Education Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
Fernando J Martinez1 Division of Pulmonary and Critical Care Medicine.
MeiLan K Han1 Division of Pulmonary and Critical Care Medicine.
SPIROMICS Investigators
Pulmonary and Critical Care Associates · USUniversity of Utah · USTemple University · USUniversity of Michigan · USBrigham and Women's Hospital · USColumbia University · USJohns Hopkins University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Iowa · USVA Ann Arbor Healthcare System · USWake Forest University · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MQUANTITATION OF HUMAN BRAIN TUMOR THERAPY RESPONSE BY MRP01CA085878 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHNSON, TIMOTHY D · 2001 to 2017
$31.9MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MPULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MParametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0MFunctional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated EmphysemaR01HL130883 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2016 to 2020
$3.6MCSRD VA I01 CX000911NCI NIH HHS P01 CA085878NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K01 HL118714NHLBI NIH HHS K23 HL128936NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL122438NHLBI NIH HHS R01 HL130883NHLBI NIH HHS R44 HL118837NHLBI NIH HHS T32 HL007749NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL137880NIA NIH HHS K08 AG031837NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIH HHS S10 OD018526WHI NIH HHS HHSN268200900009C
Abstract
rationaleAging is associated with reduced FEV
objectivesTo determine if chest computed tomography (CT)-assessed functional small airway would increase with age, even among asymptomatic individuals.
methodsWe used parametric response mapping analysis of paired inspiratory/expiratory CTs to identify functional small airway abnormality (PRM MEASUREMENTS AND MAIN
resultsAmong 580 never- and ever-smokers without obstruction or respiratory impairment, PRM
conclusionsIn never- and ever-smokers without airflow obstruction, aging is associated with increased FVC and CT-defined functional small airway abnormality regardless of respiratory symptoms.
Indexed as
AdultAgedAged, 80 and overAgingAirway ObstructionCohort StudiesCross-Sectional StudiesFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedMulticenter Studies as TopicMultivariate AnalysisPulmonary Emphysemaaginggeriatricsimaging analysislung functionspirometry
Identifiers
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Registered trials
NCT01969344ClinicalTrials.gov
NCT03263130ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.