ArticleJournal of biomedical optics2016
Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Comparison of diffuse correlation spectroscopy analytical models for cerebral blood flow measurements.Journal of biomedical optics · 2025Article
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy.ACS omega · 2024Article
- Prediction of the response to antiangiogenic sunitinib therapy by non-invasive hybrid diffuse optics in renal cell carcinoma.Biomedical optics express · 2024Article
- Interferometric near-infrared spectroscopy (iNIRS) reveals that blood flow index depends on wavelength.Biomedical optics express · 2024Article
- Cerebral tissue oxygenation response to brain irradiation measured during clinical radiotherapy.Journal of biomedical optics · 2023Article
- Extraction of tissue optical property and blood flow from speckle contrast diffuse correlation tomography (scDCT) measurements.Biomedical optics express · 2021Article
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy.Biomedical optics express · 2021Article
- Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor.Journal of biomedical optics · 2021Article
- Evaluation of antioxidant network proteins as novel prognostic biomarkers for head and neck cancer patients.Oral oncology · 2020Article
- Portable Near-Infrared Technologies and Devices for Noninvasive Assessment of Tissue Hemodynamics.Journal of healthcare engineering · 2019Review
- Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults.Neurophotonics · 2018Article
- Photoacoustic Imaging as an Early Biomarker of Radio Therapeutic Efficacy in Head and Neck Cancer.Theranostics · 2018Article
- Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics.Biomedical optics express · 2017Article
- Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging.Physiological measurement · 2017Review
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Authors and funding
11 authors.
Funding
Abstract
This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n=29) and incomplete response (IR) (n=18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO2]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO2) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μs′) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96.
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Registered trials
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