ArticlePloS one2016
Mortality Predictors in Patients with Severe Dengue in the State of Amazonas, Brazil.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Prognostic Models in Patients with Dengue: A Systematic Review.The American journal of tropical medicine and hygiene · 2025Pooled it
- Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis.Parasites & vectors · 2022Pooled it
- Different Associations betweenInternational journal of environmental research and public health · 2019Pooled it
- Temporal and spatial trends in infectious disease mortality in Amazonas, Brazil, 2013-2024: implications for surveillance.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Machine learning-based models for prediction of in-hospital mortality in patients with dengue shock syndrome.World journal of methodology · 2025Article
- Hospitalisation, mortality and years of life lost among chikungunya and dengue cases in Brazil: a nationwide cohort study, 2015-2024.Lancet regional health. Americas · 2025Article
- Epidemiology of dengue fever in Somaliland: clinical features, and serological patterns from a retrospective study.BMC infectious diseases · 2025Article
- Retrospective analysis of dengue-related fatalities in Nepal, 2022.PLOS global public health · 2025Article
- Machine-learning prediction models for any blood component transfusion in hospitalized dengue patients.Hematology, transfusion and cell therapy · 2024Article
- Article
- Development and Utility of Practical Indicators of Critical Outcomes in Dengue Patients Presenting to Hospital: A Retrospective Cross-Sectional Study.Tropical medicine and infectious disease · 2023Article
- Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue.PLoS neglected tropical diseases · 2023Article
- Factors associated with death from dengue and chikungunya virus infection during an epidemic period in Northeast Brazil: A retrospective cohort study.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean: a systematic review.Revista panamericana de salud publica = Pan American journal of public health · 2023Review
- Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation.The Lancet. Infectious diseases · 2022Review
- Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden.PLoS neglected tropical diseases · 2021Article
- Social, health system and clinical determinants of fever mortality during an outbreak of dengue fever in Kerala, India.Journal of family medicine and primary care · 2021Article
- Early hematological parameters as predictors for outcomes in children with dengue in northern India: A retrospective analysis.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models.EBioMedicine · 2020Article
- Risk Factors and Predictors of Severe Dengue in Saudi Population in Jeddah, Western Saudi Arabia: A Retrospective Study.The American journal of tropical medicine and hygiene · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue is a major public health problem in tropical and subtropical areas worldwide. There is a lack of information on the risk factors for death due to severe dengue fever in developing countries, including Brazil where the state of Amazonas is located. This knowledge is important for decision making and the implementation of effective measures for patient care. This study aimed to identify factors associated with death among patients with severe dengue, in Amazonas from 2001 to 2013. We conducted a retrospective cohort study based on secondary data from the epidemiological surveillance of dengue provided by the Fundação de Vigilância em Saúde do Amazonas, FVS (Health Surveillance Foundation) of the Secretaria de Saúde do Amazonas, SUSAM (Health Secretariat of the State of Amazonas). Data on dengue cases were obtained from the SINAN (Notifiable Diseases Information System) and SIM (Mortality Information System) databases. We selected cases of severe dengue with laboratory confirmation, including dengue-related deaths of residents in the state of Amazonas from January 1, 2001, to December 31, 2013. The explanatory variables analyzed were sex, age, level of education, spontaneous hemorrhagic manifestations, plasma extravasation and platelet count. Patients who died due to severe dengue had more hematuria, gastrointestinal bleeding, and thrombocytopenia than the survivors. Considering the simultaneous effects of demographic and clinical characteristics with a multiple logistic regression model, it was observed that the factors associated with death were age >55 years (odds ratio [OR] 4.98), gastrointestinal bleeding (OR 10.26), hematuria (OR 5.07), and thrombocytopenia (OR 2.55). Gastrointestinal bleeding was the clinical sign most strongly associated with death, followed by hematuria and age >55 years. The study results showed that the best predictor of death from severe dengue is based on the characteristic of age >55 years, together with the clinical signs of gastrointestinal bleeding, hematuria, and low platelet count.
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