ArticleNature microbiology2016
Co-delivery of cell-wall-forming enzymes in the same vesicle for coordinated fungal cell wall formation.
Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 68 citations in OpenAlex.
- The Interference ofJournal of fungi (Basel, Switzerland) · 2026Article
- Regulation of extracellular vesicles for protein secretion inMicrobial cell (Graz, Austria) · 2026Article
- Cell wall-forming chitin synthases in a chytrid fungus.Npj fungal science · 2026Article
- Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025Review
- Cell walls of filamentous fungi - challenges and opportunities for biotechnology.Applied microbiology and biotechnology · 2025Review
- Secretion and endocytosis in subapical cells support hyphal tip growth in the fungus Trichoderma reesei.Nature communications · 2025Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Structural diversification of fungal cell wall in response to the stress signaling and remodeling during fungal pathogenesis.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Breaking down barriers: comprehensive functional analysis of the Aspergillus niger chitin synthase repertoire.Fungal biology and biotechnology · 2024Article
- Regression modelling of conditional morphogene expression links and quantifies the impact of growth rate, fitness and macromorphology with protein secretion in Aspergillus niger.Biotechnology for biofuels and bioproducts · 2023Article
- Article
- Architecture of the dynamic fungal cell wall.Nature reviews. Microbiology · 2023Review
- Chitin Synthesis in Yeast: A Matter of Trafficking.International journal of molecular sciences · 2022Review
- Kinesin Motors in the Filamentous Basidiomycetes in Light of theJournal of fungi (Basel, Switzerland) · 2022Review
- Cell compensatory responses of fungi to damage of the cell wall induced by Calcofluor White and Congo Red with emphasis onFrontiers in cellular and infection microbiology · 2022Review
- Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic.Journal of fungi (Basel, Switzerland) · 2021Review
- Membrane Traffic inJournal of fungi (Basel, Switzerland) · 2021Review
- The fungicide dodine primarily inhibits mitochondrial respiration in Ustilago maydis, but also affects plasma membrane integrity and endocytosis, which is not found in Zymoseptoria tritici.Fungal genetics and biology : FG & B · 2020Article
- Characterization of Extracellular Vesicles Produced by Aspergillus fumigatus Protoplasts.mSphere · 2020Article
- Chitin and chitosan remodeling defines vegetative development and Trichoderma biocontrol.PLoS pathogens · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal cells are surrounded by an extracellular cell wall. This complex matrix of proteins and polysaccharides protects against adverse stresses and determines the shape of fungal cells. The polysaccharides of the fungal wall include 1,3-β-glucan and chitin, which are synthesized by membrane-bound synthases at the growing cell tip. A hallmark of filamentous fungi is the class V chitin synthase, which carries a myosin-motor domain. In the corn smut fungus Ustilago maydis, the myosin-chitin synthase Mcs1 moves to the plasma membrane in secretory vesicles, being delivered by kinesin-1 and myosin-5. The myosin domain of Mcs1 enhances polar secretion by tethering vesicles at the site of exocytosis. It remains elusive, however, how other cell-wall-forming enzymes are delivered and how their activity is coordinated post secretion. Here, we show that the U. maydis class VII chitin synthase and 1,3-β-glucan synthase travel in Mcs1-containing vesicles, and that their apical secretion depends on Mcs1. Once in the plasma membrane, anchorage requires enzyme activity, which suggests co-synthesis of chitin and 1,3-β-glucan polysaccharides at sites of exocytosis. Thus, delivery of cell-wall-forming enzymes in Mcs1 vesicles ensures local foci of fungal cell wall formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.