ArticleAdvanced biomedical research2016
A comparison of outcome of medical and surgical treatment of migraine headache: In 1 year follow-up.
Article in Advanced biomedical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Extracranial Trigger Site Surgery for Migraine: A Systematic Review With Meta-Analysis on Elimination of Headache Symptoms.Frontiers in neurology · 2019Pooled it
- Reliability and Accuracy of Generative Artificial Intelligence Tools in Providing General Information on Migraine Surgery.Plastic and reconstructive surgery. Global open · 2025Article
- Review
- The Use of Nerve Caps after Nerve Transection in Headache Surgery: Cadaver and Case Reports.Plastic and reconstructive surgery. Global open · 2023Article
- Outcomes of Surgical Treatment of Migraines: A Systematic Review & Meta-Analysis.Plastic surgery (Oakville, Ont.) · 2023Article
- Ultrastructural imaging reveals vascular remodeling in migraine patients.Histochemistry and cell biology · 2022Article
- Review
- Treatment of Frontal Secondary Headache Attributed to Supratrochlear and Supraorbital Nerve Entrapment With Oral Medication or Botulinum Toxin Type A vs Endoscopic Decompression Surgery.JAMA facial plastic surgery · 2018Article
- Nerve blocks for occipital headaches: A systematic review and meta-analysis.Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was designed to compare the efficacy of the medical treatment versus the surgical treatment approach to decompression of trigger point nerves in patients with migraine headaches. MATERIALS AND
methodsFifty volunteers were randomly assigned to the medical treatment group (n = 25) or the surgical treatment group (n = 25) after examination by the team neurologist to ensure a diagnosis of migraine headache. All patients received botulinum toxin type A to confirm the trigger sites. The surgical treatment group underwent surgical deactivation of the trigger site(s). The medical treatment group underwent prophylactic pharmacologic interventions by the neurologist. Pretreatment and 12-month posttreatment migraine headache frequency, duration, and intensity were analyzed and compared to determine the success of the treatments.
resultsNineteen of the 25 patients (76%) in the surgical treatment group and 10 of the 25 patients (40%) in the medical treatment group experienced a successful outcome (at least a 50% decrease in migraine frequency, duration, or intensity) after 1 year from surgery. Surgical treatment had a significantly higher success rate than medical treatment (P < 0.001). Nine patients (36%) in the surgical treatment group and one patient (4%) in the medical treatment group experienced cessation of migraine headaches. The elimination rate was significantly higher in the surgical treatment group than in the medical treatment group (P < 0.001).
conclusionsBased on the 1-year follow-up data, there is strong evidence that surgical manipulation of one or more migraine trigger sites can successfully eliminate or reduce the frequency, duration, and intensity of migraine headaches in a lasting manner.
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