ReviewCurrent obstetrics and gynecology reports
Caring for Pregnant Women with Opioid Use Disorder in the USA: Expanding and Improving Treatment.
Review in Current obstetrics and gynecology reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03718104 (Safety, Efficacy, Pharmacokinetics, and Pharmacogenomics of Extended-Release Naltrexone in Pregnant Women), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety, Efficacy, Pharmacokinetics, and Pharmacogenomics of Extended-Release Naltrexone in Pregnant Women
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Barriers to opioid replacement therapy in pregnant women with opioid use disorder: a systematic review.Substance abuse treatment, prevention, and policy · 2025Pooled it
- Guideline
- Social determinants of health associated with newly documented opioid-related postpartum readmissions.Pregnancy (Hoboken, N.J.) · 2026Article
- Bringing MOUD "In House": Implementing an Internal MOUD Program During Pregnancy in a State Prison.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2026Article
- Overdose Data to Action: A qualitative analysis of funded activities tailored for women.Journal of substance use and addiction treatment · 2025Article
- Early parent-child interaction and home environments of children exposed prenatally to opioids: A comparison of biological mothers and out-of-home caregivers.Infant mental health journal · 2025Article
- Substance use and use disorders during pregnancy and the postpartum period.American journal of obstetrics and gynecology · 2025Review
- Beyond a simple cause and effect relationship: Exploring the long-term outcomes of children prenatally exposed to opioids and other substances.Seminars in perinatology · 2025Review
- Let us be heard: critical analysis and debate of collaborative research approaches used in implementation science research with equity-deserving populations.Implementation science communications · 2025Article
- A credibility-driven evaluation of a community-based perinatal substance use disorder collaborative care model.Frontiers in public health · 2025Article
- Evaluating the Effect of Maternal Opioid Maintenance Dose on the NOWS-COS Outcome Criteria: A Pilot Study.Clinical pediatrics · 2024Article
- Prescription psychostimulant use, admissions and treatment initiation and retention in pregnant people with opioid use disorder.Nature. Mental health · 2024Article
- Neurobehavioral outcomes of infants exposed to buprenorphine-naloxone compared with naltrexone during pregnancy.Early human development · 2024Article
- Development of an Educational Brochure about Treatment Options for Pregnant Women with Opioid Use Disorders.Pharmacy (Basel, Switzerland) · 2024Article
- Maternal opioid use disorder and infant mortality in Wisconsin, United States, 2010-2018.Preventive medicine · 2024Article
- Telehealth Treatment for Opioid Use Disorder During Pregnancy.JAMA network open · 2024Article
- Supporting the implementation of written exposure therapy for posttraumatic stress disorder in an obstetrics-substance use disorder clinic in the Northeastern United States.SSM. Mental health · 2023Article
- Strengthening the System Supporting Perinatal People with Substance Use Disorder in the Midwest Using Group Model Building.Maternal and child health journal · 2023Article
- Impact of an Asynchronous Training for the Early Intervention and Childcare Workforce Addressing the Developmental Impact of the Opioid Crisis on Young Children.Maternal and child health journal · 2023Review
- Initiation and Treatment Discontinuation of Medications for Opioid Use Disorder in Pregnant People Compared With Nonpregnant People.Obstetrics and gynecology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the reviewOpioid use disorder in the USA is rising at an alarming rate, particularly among women of childbearing age. Pregnant women with opioid use disorder face numerous barriers to care, including limited access to treatment, stigma, and fear of legal consequences. This review of opioid use disorder in pregnancy is designed to assist health care providers caring for pregnant and postpartum women with the goal of expanding evidence-based treatment practices for this vulnerable population. RECENT
findingsWe review current literature on opioid use disorder among US women, existing legislation surrounding substance use in pregnancy, and available treatment options for pregnant women with opioid use disorder. Opioid agonist treatment (OAT) remains the standard of care for treating opioid use disorder in pregnancy. Medically assisted opioid withdrawal ("detoxification") is not recommended in pregnancy and is associated with high maternal relapse rates. Extended release naltrexone may confer benefit for carefully selected patients. Histories of trauma and mental health disorders are prevalent in this population; and best practice recommendations incorporate gender-specific, trauma-informed, mental health services. Breastfeeding with OAT is safe and beneficial for the mother-infant dyad. SUMMARY: Further research investigating options of OAT and the efficacy of opioid antagonists in pregnancy is needed. The US health care system can adapt to provide quality care for these mother-infant dyads by expanding comprehensive treatment services and improving access to care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.