Evidence map›Paper›PMID 27563490›Full record

ArticleJournal of pathology informatics2016

NDER: A novel web application using annotated whole slide images for rapid improvements in human pattern recognition.

Nicholas P Reder, Daniel Glasser, Suzanne M Dintzis, Mara H Rendi, Rochelle L Garcia, Jonathan C Henriksen, Mark R Kilgore

Open access · goldAbstract read
In one paragraph

Article in Journal of pathology informatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nicholas P RederDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Daniel GlasserDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Suzanne M DintzisDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Mara H RendiDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Rochelle L GarciaDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Jonathan C HenriksenDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Mark R KilgoreDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
University of Washington Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextWhole-slide images (WSIs) present a rich source of information for education, training, and quality assurance. However, they are often used in a fashion similar to glass slides rather than in novel ways that leverage the advantages of WSI. We have created a pipeline to transform annotated WSI into pattern recognition training, and quality assurance web application called novel diagnostic electronic resource (NDER).

aimsCreate an efficient workflow for extracting annotated WSI for use by NDER, an attractive web application that provides high-throughput training. MATERIALS AND

methodsWSI were annotated by a resident and classified into five categories. Two methods of extracting images and creating image databases were compared. Extraction Method 1: Manual extraction of still images and validation of each image by four breast pathologists. Extraction Method 2: Validation of annotated regions on the WSI by a single experienced breast pathologist and automated extraction of still images tagged by diagnosis. The extracted still images were used by NDER. NDER briefly displays an image, requires users to classify the image after time has expired, then gives users immediate feedback.

resultsThe NDER workflow is efficient: annotation of a WSI requires 5 min and validation by an expert pathologist requires An additional one to 2 min. The pipeline is highly automated, with only annotation and validation requiring human input. NDER effectively displays hundreds of high-quality, high-resolution images and provides immediate feedback to users during a 30 min session.

conclusionsNDER efficiently uses annotated WSI to rapidly increase pattern recognition and evaluate for diagnostic proficiency.

Indexed as

Adaptive learningpathology educationsmartphoneweb applicationwhole-slide images

Identifiers

PMID27563490
PMCPMC4977980
OpenAlexW2480793153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.