ArticleFrontiers in aging neuroscience2016
Does Cognitive Impairment Affect Rehabilitation Outcome in Parkinson's Disease?
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Exercise Specialists' Evaluation of Robot-Led Rehabilitative Exercise for People with Parkinson's Disease.Healthcare (Basel, Switzerland) · 2025Article
- Altered Neurovascular Coupling for Multidisciplinary Intensive Rehabilitation in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Activities of Daily Living Are Improved by Inpatient Multimodal Complex Treatment for PD-a Real-World Cohort Study.Movement disorders clinical practice · 2023Article
- Effect of music-based movement therapy on the freezing of gait in patients with Parkinson's disease: A randomized controlled trial.Frontiers in aging neuroscience · 2022Article
- Efficacy of short-term multidisciplinary intensive rehabilitation in patients with different Parkinson's disease motor subtypes: a prospective pilot study with 3-month follow-up.Neural regeneration research · 2021Article
- Occupational Therapy for Parkinsonian Patients: A Retrospective Study.Parkinson's disease · 2019Article
- Is the aquatic thermal environment a suitable place for providing rehabilitative treatment for person with Parkinson's disease? A retrospective study.International journal of biometeorology · 2019Article
- Romberg ratio coefficient in quiet stance and postural control in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- The many facets of motor learning and their relevance for Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Review
- Focused and Sustained Attention Is Modified by a Goal-Based Rehabilitation in Parkinsonian Patients.Frontiers in behavioral neuroscience · 2017Article
- Impact of Mézières Rehabilitative Method in Patients with Parkinson's Disease: A Randomized Controlled Trial.Parkinson's disease · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before.
objectiveThis study is aimed to evaluate the impact of cognitive decline on rehabilitation outcomes in patients with PD.
methodsWe retrospectively identified 485 patients with PD hospitalized for a 4-week Multidisciplinary Intensive Rehabilitation Treatment (MIRT) between January 2014 and September 2015. According to Mini Mental State Examination (MMSE), patients were divided into: group 1-normal cognition (score 27-30), group 2-mild cognitive impairment (score 21-26), group 3-moderate or severe cognitive impairment (score ≤ 20). According to Frontal Assessment Battery (FAB), subjects were divided into patients with normal (score ≥13.8) and pathological (score <13.8) executive functions. The outcome measures were: Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Disability Scale (PDDS), Six Minutes Walking Test (6MWT), Timed Up and Go Test (TUG) and Berg Balance Scale (BBS).
resultsAll scales had worse values with the increase of cognitive impairment and passing from normal to pathological executive functions. After rehabilitation, all the outcome measures improved in all groups (p < 0.0001). Between groups, the percentage of improvement was significantly different for total UPDRS (p = 0.0009, best improvement in normal MMSE group; p = 0.019, best improvement in normal FAB group), and BBS (p < 0.0001, all pairwise comparisons significant, best improvement in patients with worse MMSE score; p < 0.0001, best improvement in patients with pathological FAB). TUG (p = 0.006) and BBS (p < 0.0001) improved in patients with pathological FAB score, more than in those with normal FAB score.
conclusionsPatients gain benefit in the rehabilitative outcomes, regardless of cognition. Our data suggest that rehabilitation could be effective also in Parkinsonian subjects with cognitive impairment, as well as with dysexecutive syndrome.
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