ArticleThe Journal of biological chemistry2016
Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex.
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Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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0cells of the map it votes in
36citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.Acta neuropathologica communications · 2026Article
- A phase separation hypothesis for the biological function of PrP: the role of multivalent interactions at the plasma membrane.Biochemical Society transactions · 2026Review
- Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Characterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling.Lab animal · 2025Article
- DEAD-Box Helicase 6 Blockade in Brain-Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity.MedComm · 2025Article
- The role of the FKBP51-Hsp90 complex in Alzheimer's disease: An emerging new drug target.Cell stress & chaperones · 2024Review
- Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice.Science signaling · 2024Article
- Potential Application of MicroRNAs and Some Other Molecular Biomarkers in Alzheimer's Disease.Current issues in molecular biology · 2024Review
- Amyloid-βiScience · 2023Article
- Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein.Cell and tissue research · 2023Review
- Detecting Early Cognitive Decline in Alzheimer's Disease with Brain Synaptic Structural and Functional Evaluation.Biomedicines · 2023Review
- Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.Science translational medicine · 2022Article
- Group I mGluRs in Therapy and Diagnosis of Parkinson's Disease: Focus on mGluR5 Subtype.Biomedicines · 2022Review
- Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.Frontiers in cell and developmental biology · 2022Article
- Review
- A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain.Journal of neurochemistry · 2020Review
- Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease.Acta neuropathologica communications · 2020Article
- Show Me Your Friends and I Tell You Who You Are: The Many Facets of Prion Protein in Stroke.Cells · 2020Review
- The Interplay between CaInternational journal of molecular sciences · 2019Review
- Fragile X and APP: a Decade in Review, a Vision for the Future.Molecular neurobiology · 2019Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Flavio H BeraldoFrom the Robarts Research Institute and.ORCID http://orcid.org/0000-0001-7638-2007
Valeriy G OstapchenkoFrom the Robarts Research Institute and.
Fabiana A CaetanoFrom the Robarts Research Institute and the Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5B7,Canada.
Andre L S GuimaraesFrom the Robarts Research Institute and the Universidade Estadual de Montes Claros, Montes Claros, MG 39401-089, Brazil.
Giulia D S FerrettiFrom the Robarts Research Institute and the Programa de Biologia Estrutural, Instituto de Bioquimica Medica Leopoldo de Meis, Instututo Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonacia Magnetica Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
Nathalie Daudethe Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada.
Lisa Bertramthe Center for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Katiane O P C NogueiraFrom the Robarts Research Institute and the Instituto de Ciências Exatas e Biológicas, Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro S/N, Ouro Preto, Minas Gerais 35400-000, Brazil.
Jerson L Silvathe Programa de Biologia Estrutural, Instituto de Bioquimica Medica Leopoldo de Meis, Instututo Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonacia Magnetica Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
David Westawaythe Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada.
Neil R Cashmanthe Center for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Vilma R Martinsthe International Center for Research and Education, A. C. Camargo Cancer Center, São Paulo, SP CEP 01509-010, Brazil, and.
Vania F PradoFrom the Robarts Research Institute and the Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5B7,Canada, the Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Marco A M PradoFrom the Robarts Research Institute and the Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5B7,Canada, the Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7, Canada mprado@robarts.ca.
Robarts Clinical Trials · CAWestern University · CAUniversidade Federal do Rio de Janeiro · BRUniversity of Alberta · CAUniversity of British Columbia · CAAC Camargo Hospital · BRUniversidade Federal de Ouro Preto · BR
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prion protein (PrP
Indexed as
Protein MultimerizationAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCalciumCalcium SignalingMiceMice, KnockoutNeuronsPeptide FragmentsPrion DiseasesProtein TransportPrPC ProteinsReceptor, Metabotropic Glutamate 5Amyloid beta-Peptidesamyloid beta-protein (1-42)CalciumGrm5 protein, mousePeptide FragmentsPrPC ProteinsReceptor, Metabotropic Glutamate 5Alzheimer diseasecalciumlamininmetabotropic glutamate receptor 5metabotropic glutamate receptor (mGluR)prionProtein trafficking
Identifiers
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Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.