Evidence map›Paper›PMID 27562866›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Heterogeneous incidence and propagation of spreading depolarizations.

Dan Kaufmann, Jeremy J Theriot, Jekaterina Zyuzin, C Austin Service, Joshua C Chang, Y Tanye Tang, Vladimir B Bogdanov, Sylvie Multon, Jean Schoenen, Y Sungtaek Ju and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 51 citations in OpenAlex.

  1. Hemiplegic migraine: genetics and pathophysiology.The Journal of clinical investigation · 2026
    Review
  2. Article
  3. Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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  15. Article
  16. Anoxic spreading depolarization in the neonatal rat cortexFrontiers in cellular neuroscience · 2023
    Article
  17. Depth-profile of impairments in endothelin-1 - induced focal cortical ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Dan Kaufmann1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Jeremy J Theriot1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Jekaterina Zyuzin2 Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
C Austin Service1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Joshua C Chang3 Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda, MD, USA.
Y Tanye Tang5 Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Vladimir B Bogdanov1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Sylvie Multon6 Department of Neurology, University of Liège, Liège, Belgium.
Jean Schoenen6 Department of Neurology, University of Liège, Liège, Belgium.
Y Sungtaek Ju5 Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, USA.
K C Brennan1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.
University of California, Los Angeles · USUniversity of Utah · USUniversity of Liège · BEThe Ohio State University · US

Funding

Sensory plasticity in migraineR01NS085413 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2013 to 2017
$1.7M
NINDS NIH HHS R01 NS085413
6 · The paper itself

Abstract

Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically, apparently not respecting the anatomic, synaptic, functional, or vascular architecture of the brain. However, there is evidence that spreading depolarizations are not truly concentric, isotropic, or homogeneous, either in space or in time. Here we present evidence from KCl-induced spreading depolarizations, in mouse and rat, in vivo and in vitro, showing the great variability that these depolarizations can exhibit. This variability can help inform the mechanistic understanding of spreading depolarizations, and it has implications for their phenomenology in neurologic disease.

Indexed as

Models, NeurologicalAnimalsBrainCortical Spreading DepressionHemodynamicsIn Vitro TechniquesMaleMice, Inbred C57BLOptical ImagingPotassium ChlorideRats, Sprague-DawleyWavelet AnalysisPotassium Chlorideanisotropycortical spreading depressionSpreading depolarizationsusceptibilityvelocity

Identifiers

PMID27562866
PMCPMC5435294
OpenAlexW2516202658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.