Evidence map›Paper›PMID 27562843›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2017

Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans.

Steven A Romero, Jennifer L McCord, Matthew R Ely, Dylan C Sieck, Tahisha M Buck, Meredith J Luttrell, David A MacLean, John R Halliwill

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Lactate in Anaphylaxis: 100 Years On.Sports medicine (Auckland, N.Z.) · 2025
    Review
  8. Article
  9. Article
  10. Cyclooxygenase inhibition does not blunt thermal hyperemia in skeletal muscle of humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Physical Activity and Hypertension.Reviews in cardiovascular medicine · 2022
    Review
  17. Acute heat exposure improves microvascular function in skeletal muscle of aged adults.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Steven A RomeroDepartment of Human Physiology, University of Oregon, Eugene, Oregon; and.
Jennifer L McCordDepartment of Human Physiology, University of Oregon, Eugene, Oregon; and.
Matthew R ElyDepartment of Human Physiology, University of Oregon, Eugene, Oregon; and.
Dylan C SieckDepartment of Human Physiology, University of Oregon, Eugene, Oregon; and.
Tahisha M BuckDepartment of Human Physiology, University of Oregon, Eugene, Oregon; and.
Meredith J LuttrellDepartment of Human Physiology, University of Oregon, Eugene, Oregon; and.
David A MacLeanDivision of Medical Sciences, Northern Ontario School of Medicine, Sudbury, Ontario, Canada.
John R HalliwillDepartment of Human Physiology, University of Oregon, Eugene, Oregon; and halliwil@uoregon.edu.ORCID http://orcid.org/0000-0003-3001-1715
University of Oregon · USNOSM University · CA

Funding

Exercise, Histamine Receptors, & Vascular Health In AgingR01HL115027 · NHLBI · UNIVERSITY OF OREGON · PI HALLIWILL, JOHN R. · 2013 to 2016
$1.8M
NHLBI NIH HHS R01 HL115027
6 · The paper itself

Abstract

In humans, acute aerobic exercise elicits a sustained postexercise vasodilation within previously active skeletal muscle. This response is dependent on activation of histamine H

Indexed as

Blood Flow VelocityCell DegranulationExerciseFemaleHistamineHumansMaleMast CellsMuscle, SkeletalVasodilationYoung AdultHistamineextracellular fluidhistaminemicrodialysispostexercise hypotensionregional blood flow

Identifiers

PMID27562843
PMCPMC5401950
OpenAlexW2514350977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.