Evidence map›Paper›PMID 27562793›Full record

ReviewAmino acids2017

P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis?

Daniel Aeschlimann, Vera Knäuper

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Amino acids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. The P2X7 Receptor in Autoimmunity.International journal of molecular sciences · 2023
    Review
  3. Osteoclast Multinucleation: Review of Current Literature.International journal of molecular sciences · 2020
    Review
  4. Transglutaminases in Monocytes and Macrophages.Medical sciences (Basel, Switzerland) · 2018
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel AeschlimannMatrix Biology and Tissue Repair Research Unit, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff, CF14 4XY, UK. AeschlimannDP@Cardiff.ac.uk.ORCID 0000-0003-0930-7706
Vera KnäuperMatrix Biology and Tissue Repair Research Unit, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff, CF14 4XY, UK.

Funding

Versus Arthritis 18461Versus Arthritis 20512
6 · The paper itself

Abstract

Transglutaminases have important roles in stabilizing extracellular protein assemblies in tissue repair processes but some reaction products can stimulate immune activation, leading to chronic inflammatory conditions or autoimmunity. Exacerbated disease in models of inflammatory arthritis has been ascribed to sustained extracellular enzyme activity alongside formation of select protein modifications. Here, we review the evidence, with a focus on the link between P2X7R signaling and TG2 export, a pathway that we have recently discovered which ties extracellular protein modifications into the danger signal-mediated innate immune response. These recent insights offer new opportunities for therapeutic intervention.

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidAutoimmunityBone and BonesCartilageCytokinesGene Expression RegulationGTP-Binding ProteinsHumansImmunity, InnateInflammasomesInflammationNLR Family, Pyrin Domain-Containing 3 ProteinProtein Glutamine gamma Glutamyltransferase 2Protein TransportCytokinesGTP-Binding ProteinsInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanProtein Glutamine gamma Glutamyltransferase 2Receptors, Purinergic P2X7TransglutaminasesArthritisAutoimmunityCartilageInflammationP2X7 receptorPurinergic signalingTransglutaminase

Identifiers

PMID27562793
PMCPMC5332493

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.