Evidence map›Paper›PMID 27562686›Full record

ArticleMolecular imaging and biology2017

Imaging α4β2 Nicotinic Acetylcholine Receptors (nAChRs) in Baboons with [

Hiroto Kuwabara, Yongjun Gao, Michael Stabin, Jennifer Coughlin, Sridhar Nimmagadda, Robert F Dannals, Martin G Pomper, Andrew G Horti

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Article
  7. Article
  8. Human biodistribution and dosimetry of [Nuclear medicine and biology · 2017
    Article
  9. [Synapse (New York, N.Y.) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hiroto KuwabaraDepartment of Radiology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA. hkuwaba1@jhmi.edu.ORCID 0000-0003-2082-9054
Yongjun GaoDepartment of Radiology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Michael StabinDepartment of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.
Jennifer CoughlinDepartment of Psychiatry, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Sridhar NimmagaddaDepartment of Radiology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Robert F DannalsDepartment of Radiology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Martin G PomperDepartment of Radiology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Andrew G HortiDepartment of Radiology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USVanderbilt University · US

Funding

Extrathalamic nAChR-PET for Imaging NeurodegenerationR21AG037298 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G, POMPER, MARTIN G · 2011 to 2011
$235k
NIA NIH HHS R21 AG037298
6 · The paper itself

Abstract

purposeCurrently available positron-emitting radiotracers for imaging of the α4β2 subtype of nicotinic acetylcholine receptors (nAChRs) exhibit high and moderate specific binding in the thalamus and extra-thalamic brain regions, respectively. In many neuropsychiatric disorders, α4β2-nAChRs are altered in the extra-thalamic brain regions, but not necessarily in the thalamus. The purpose of this study was to evaluate [ PROCEDURES: The regional distribution of [

results[

conclusion[

Indexed as

2,2'-DipyridylAnimalsAzabicyclo CompoundsMaleMiceMolecular ImagingPapioPositron-Emission TomographyRadiometryRadiopharmaceuticalsReceptors, NicotinicThalamusTime FactorsTissue Distribution2,2'-DipyridylAzabicyclo Compoundsnicotinic receptor alpha4beta2RadiopharmaceuticalsReceptors, NicotinicBinding potentialDosimetryNon-human primatesPET imagingRadioligandsα4β2 nicotinic acetylcholine receptors

Identifiers

PMID27562686
OpenAlexW2510913709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.