ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2017
Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Microbial influencers: the airway microbiome's role in asthma.The Journal of clinical investigation · 2025Review
- The impact of prenatal dog keeping on infant gut microbiota development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study.PloS one · 2023Article
- Effect of prenatal dog exposure on eczema development in early and late childhood.The journal of allergy and clinical immunology. In practice · 2022Article
- Place of residence, gender, month of birth and age influence on the concentration of specific IgE antibodies in serum. The Epidemiology of Allergic Diseases in Poland (ECAP survey): part three.Postepy dermatologii i alergologii · 2022Article
- Stimulation of an immune system by different types of allergens causes seasonal (late spring and summer) factors to increase probability of allergic rhinitis symptoms. The Epidemiology of Allergic Diseases in Poland (ECAP) survey: part two.Postepy dermatologii i alergologii · 2021Article
- Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Review
- Dog keeping at home before and during pregnancy decreased the risk of food allergy in 1-year-old children.Postepy dermatologii i alergologii · 2020Article
- Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children.Current allergy and asthma reports · 2019Review
- Environmental determinants of allergy and asthma in early life.The Journal of allergy and clinical immunology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe effect of dog exposure on the risk of children developing allergic disease remains controversial. Many analyses have not considered that associations may vary within population subgroups.
objectiveTo examine whether associations between living with a dog in the first year of life and allergic outcomes vary within subgroups selected a priori (race, gender and delivery mode).
methodsBlack (n = 496) and White (n = 196) children enrolled in the WHEALS birth cohort study had a clinical examination at age 2 years to assess eczema and allergen-specific IgE (sIgE) and perform skin prick testing (SPT). Whether the child lived with an indoor dog in the first year of life was assessed through interview, as was doctor diagnosis of asthma at ages 3-6 years.
resultsLiving with a dog was associated with decreased odds of having ≥ 1 positive SPT (OR = 0.56, 95% CI: 0.34, 0.91) and having eczema (OR = 0.34, 95% CI: 0.20, 0.60). The association with SPT was stronger in those children born via caesarean section (c-section) vs. vaginally (OR = 0.29, 95% CI: 0.12, 0.74 vs. OR = 0.76, 95% CI: 0.43, 1.37, respectively, interaction P = 0.087) and in those who were firstborn vs. not (OR = 0.27, 95% CI: 0.11, 0.67 vs. OR = 0.82, 95% CI: 0.45, 1.47, respectively, interaction P = 0.044). The association with eczema was stronger in children born vaginally compared with those born via caesarean section (OR = 0.17, 95% CI: 0.06, 0.43 vs. OR = 0.65, 95% CI: 0.31, 1.35, respectively, interaction P = 0.025) and was stronger in Black vs. White children (OR = 0.30, 95% CI: 0.15, 0.61 vs. OR = 0.78, 95% CI: 0.29, 2.11, respectively, interaction P = 0.12). Dog keeping was not significantly inversely associated with having ≥ 1 elevated sIgE and only approached statistical significance with asthma. CONCLUSIONS AND CLINICAL RELEVANCE: Results likely vary between studies due to variability of specific exposure-outcome associations in subgroups defined by other factors as well as the relative distributions of those subgroups. Important allergic disorder associations will be missed without subgroup analyses.
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