Trial reportScientific reports2016
Skeletal muscle ATP synthesis and cellular H(+) handling measured by localized (31)P-MRS during exercise and recovery.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03800342 (Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pooled it
- Effects of 4-week continuous hypoxic training on skeletal muscle oxygenation using near-infrared spectroscopy and functional magnetic resonance imaging.European journal of applied physiology · 2026Trial
- Dynamic multivoxel-localizedNMR in biomedicine · 2018Trial
- Effects of Rumen-Protected β-Alanine on Hepatic Gluconeogenesis-Related Indices and Muscle Energy Metabolism in Transported Cattle.Animals : an open access journal from MDPI · 2026Article
- Combined 31P and 1H MRS show that impaired muscle O2 supply limits ATP synthesis during exercise in systemic sclerosis.Clinical science (London, England : 1979) · 2026Article
- A Novel 9-ChannelMagnetic resonance in medicine · 2026Article
- pH-Resolved ATP Synthesis in Skeletal Muscle: Concept, Implementation, and Assessment Using DynamicDiagnostics (Basel, Switzerland) · 2026Article
- HFrontiers in molecular biosciences · 2026Article
- Article
- Skeletal Muscle Quantity Versus Quality in Heart Failure: Exercise Intolerance and Outcomes in Older Patients With HFpEF Are Related to Abnormal Skeletal Muscle Metabolism Rather Than Age-Related Skeletal Muscle Loss.Circulation. Heart failure · 2025Article
- Cumulative effects of HThe Journal of physiology · 2025Article
- Cardio-rheumatology: integrated care and the opportunities for personalized medicine.Therapeutic advances in musculoskeletal disease · 2025Review
- Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleavedScientific reports · 2024Article
- Postcontraction [acetylcarnitine] reflects interindividual variation in skeletal muscle ATP production patterns in vivo.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Increased adiposity is associated with altered skeletal muscle energetics.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Evaluation of Acute Supplementation With the Ketone Ester (Frontiers in physiology · 2022Article
- A Modular Mathematical Model of Exercise-Induced Changes in Metabolism, Signaling, and Gene Expression in Human Skeletal Muscle.International journal of molecular sciences · 2021Article
- Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review.Nutrients · 2021Review
- Musculoskeletal MRI at 7 T: do we need more or is it more than enough?European radiology experimental · 2020Review
- InterleavedMagnetic resonance in medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
(31)P magnetic resonance spectroscopy (MRS) is widely used for non-invasive investigation of muscle metabolism dynamics. This study aims to extend knowledge on parameters derived from these measurements in detail and comprehensiveness: proton (H(+)) efflux, buffer capacity and the contributions of glycolytic (L) and oxidative (Q) rates to ATP synthesis were calculated from the evolutions of phosphocreatine (PCr) and pH. Data are reported for two muscles in the human calf, for each subject and over a wide range of exercise intensities. 22 subjects performed plantar flexions in a 7T MR-scanner, leading to PCr changes ranging from barely noticeable to almost complete depletion, depending on exercise protocol and muscle studied by localized MRS. Cytosolic buffer capacity was quantified for the first time non-invasively and individually, as was proton efflux evolution in early recovery. Acidification started once PCr depletion reached 60-75%. Initial and end-exercise L correlated with end-exercise levels of PCr and approximately linear with pH. Q calculated directly from PCr and pH derivatives was plausible, requiring fewer assumptions than the commonly used ADP-model. In conclusion, the evolution of parameters describing cellular energy metabolism was measured over a wide range of exercise intensities, revealing a relatively complete picture of muscle metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.