ArticleScientific reports2016
The functional and predictive roles of miR-210 in cryptorchidism.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07315737 (miRNAs Associated With Undescended and Retractile Testes), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
miRNAs Associated With Undescended and Retractile Testes
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Exploring dysregulated miRNAs in cryptorchidism: a systematic review.The Journal of international medical research · 2021Pooled it
- Could miRNAs be used as markers for distinguishing undescended testes from retractile testes? A prospective controlled pilot/exploratory study.BMC urology · 2026Observational
- Functions and targets of miRNAs in pharmacological and toxicological effects of major components of Tripterygium wilfordii Hook F.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Impacts of non-coding RNAs in the pathogenesis of varicocele.Molecular biology reports · 2024Review
- Elevated plasma miR-210 expression is associated with atypical genitalia in patients with 46,XY differences in sex development.Molecular genetics & genomic medicine · 2022Article
- The Role of microRNAs in the Gonocyte Theory as Target of Malignancy: Looking for Potential Diagnostic Biomarkers.International journal of molecular sciences · 2022Review
- The gene regulatory role of non-coding RNAs in non-obstructive azoospermia.Frontiers in endocrinology · 2022Review
- MicroRNA-210 Regulates Endoplasmic Reticulum Stress and Apoptosis in Porcine Embryos.Animals : an open access journal from MDPI · 2021Article
- Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis.Frontiers in immunology · 2021Article
- IL-6-miR-210 Suppresses Regulatory T Cell Function and Promotes Atrial Fibrosis by Targeting Foxp3.Molecules and cells · 2020Article
- Article
- Exosomes derived from cancer stem cells of gemcitabine-resistant pancreatic cancer cells enhance drug resistance by delivering miR-210.Cellular oncology (Dordrecht, Netherlands) · 2020Article
- miR-34c disrupts spermatogonial stem cell homeostasis in cryptorchid testes by targeting Nanos2.Reproductive biology and endocrinology : RB&E · 2018Article
- Altered miRNA profile in testis of post-cryptorchidopexy patients with non-obstructive azoospermia.Reproductive biology and endocrinology : RB&E · 2018Article
- Association between RNA-binding protein Ptbp2 and germ cell injury in an experimentally-induced unilateral cryptorchidism murine model.PloS one · 2017Article
- Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia.Asian journal of andrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic diseases of the reproductive system are important factors leading to male infertility. Many studies have shown that microRNAs (miRNAs) regulate the expression of multiple genes that play a significant role in spermatogenesis and development. We previously showed that microRNA-210 (miR-210) is one of the markedly upregulated microRNAs in the testes of sterile males with maturation arrest (MA). However, the role of miR-210 in spermatogenesis remains unknown. In this study, we found that miR-210 is highly expressed not only in patients with MA but also in patients with cryptorchidism. In addition, miR-210 inhibits the expression of Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) both in vitro and in vivo, particularly in cryptorchidic tissues. To facilitate further research, we established a mouse model of cryptorchidism and were surprised to discover that the miR-210 expression pattern was in accordance with that of patients with cryptorchidism. Thus, we propose that miR-210 may serve as a biomarker of cryptorchidism in clinical tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.