Evidence map›Paper›PMID 27562178›Full record

ArticleMolecular neurobiology2017

Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.

Hong Chang, Lingyi Li, Tao Peng, Maria Grigoroiu-Serbanescu, Sarah E Bergen, Mikael Landén, Christina M Hultman, Andreas J Forstner, Jana Strohmaier, Julian Hecker and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 8 institutions in 9 countries.

Hong ChangKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, People's Republic of China.
Lingyi LiKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, People's Republic of China.
Tao PengKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, People's Republic of China.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Sarah E BergenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Christina M HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Julian HeckerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, Munich, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sven CichonInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Stéphane JamainInserm U 955, IMRB, Psychiatrie Translationnelle, Créteil, France.
Marion LeboyerInserm U 955, IMRB, Psychiatrie Translationnelle, Créteil, France.
Frank BellivierInserm U 955, IMRB, Psychiatrie Translationnelle, Créteil, France.
Bruno EtainInserm U 955, IMRB, Psychiatrie Translationnelle, Créteil, France.
Jean-Pierre KahnFondation Fondamental, Créteil, France.
Chantal HenryInserm U 955, IMRB, Psychiatrie Translationnelle, Créteil, France.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Swedish Bipolar Study Group
MooDS Consortium
Xiao XiaoKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, People's Republic of China. xiaoxiao.whu05@gmail.com.
Ming LiKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, People's Republic of China. limingkiz@mail.kiz.ac.cn.ORCID http://orcid.org/0000-0002-8197-6552
Kunming Institute of Zoology · CNUniversity of Bonn · DEInserm · FRBroad Institute · USGoethe University Frankfurt · DEBlack Dog Institute · AUKarolinska Institutet · SEUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide analysis (GWA) is an effective strategy to discover extreme effects surpassing genome-wide significant levels in studying complex disorders; however, when sample size is limited, the true effects may fail to achieve genome-wide significance. In such case, there may be authentic results among the pools of nominal candidates, and an alternative approach is to consider nominal candidates but are replicable across different samples. Here, we found that mRNA expression of the choline dehydrogenase gene (CHDH) was uniformly upregulated in the brains of bipolar disorder (BPD) patients compared with healthy controls across different studies. Follow-up genetic analyses of CHDH variants in multiple independent clinical datasets (including 11,564 cases and 17,686 controls) identified a risk SNP rs9836592 showing consistent associations with BPD (P

Indexed as

Genetic Predisposition to DiseaseAdultBipolar DisorderBrainCholine DehydrogenaseChromosomes, Human, Pair 3FemaleGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMalePhenotypePolymorphism, Single NucleotideCholine DehydrogenaseBipolar disorderCHDHCognitive abilityExpression quantitative trait loci (eQTL)Gene expressionGenetic evidence

Identifiers

PMID27562178
OpenAlexW2507382458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.