ArticleProceedings of the National Academy of Sciences of the United States of America2016
Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 99 citations in OpenAlex.
- Molecular Imaging of In Vivo Zinc Distribution Using Nuclear and Magnetic Resonance Imaging.Chemical & biomedical imaging · 2026Review
- Deuterated Molecular Probes for Metal Sensing.ACS omega · 2026Article
- Lighting up β-cell function: Noninvasive MRI of glucose-stimulated ZnMagnetic resonance letters · 2026Article
- Molecular MRI of Dysregulated Zinc Secretion Detects Pancreatic Ductal Adenocarcinoma and Response to KRASG12D Inhibitor Treatment.Cancer research · 2025Article
- Zn(II)-Responsive MRI Probe Based on an Fe(III) Macrocyclic Complex.Inorganic chemistry · 2024Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- A Reactive and Specific Sensor for Activity-BasedACS sensors · 2024Article
- Application of HInternational journal of molecular sciences · 2024Article
- Impact of dietary zinc on stimulated zinc secretion MRI in the healthy and malignant mouse prostate.Npj imaging · 2024Article
- A Semisynthetic Bioluminescence Sensor for Ratiometric Imaging of Metal Ions In Vivo Using DNAzymes Conjugated to An Engineered Nano-Luciferase.Angewandte Chemie (International ed. in English) · 2023Article
- Rational design of a genetically encoded NMR zinc sensor.Chemical science · 2023Article
- MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Using micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022Article
- Urinary Zinc Loss Identifies Prostate Cancer Patients.Cancers · 2022Article
- Carbon sources and pathways for citrate secreted by human prostate cancer cells determined by NMR tracing and metabolic modeling.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways.Frontiers in immunology · 2022Article
- Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021Review
- Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021Article
- RGD-Peptide Functionalization Affects theJournal of medicinal chemistry · 2021Article
- Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Many secretory tissues release Zn(II) ions along with other molecules in response to external stimuli. Here we demonstrate that secretion of Zn(II) ions from normal, healthy prostate tissue is stimulated by glucose in fasted mice and that release of Zn(II) can be monitored by MRI. An ∼50% increase in water proton signal enhancement is observed in T1-weighted images of the healthy mouse prostate after infusion of a Gd-based Zn(II) sensor and an i.p. bolus of glucose. Release of Zn(II) from intracellular stores was validated in human epithelial prostate cells in vitro and in surgically exposed prostate tissue in vivo using a Zn(II)-sensitive fluorescent probe known to bind to the extracellular surface of cells. Given the known differences in intracellular Zn(II) stores in healthy versus malignant prostate tissues, the Zn(II) sensor was then evaluated in a transgenic adenocarcinoma of the mouse prostate (TRAMP) model in vivo. The agent proved successful in detecting small malignant lesions as early as 11 wk of age, making this noninvasive MR imaging method potentially useful for identifying prostate cancer in situations where it may be difficult to detect using current multiparametric MRI protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.