ArticleThe Journal of physiology2016
Endothelium-dependent vasodilatory signalling modulates α
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Amplification of endothelium-dependent vasodilatation in contracting human skeletal muscle: role of KThe Journal of physiology · 2019Trial
- The Emerging Role of Endothelial Ion Channels in the Control of Human Microcirculation.International journal of molecular sciences · 2026Review
- Endogenous muscarinic acetylcholine receptor signaling blunts αAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Functional sympatholysis of neuropeptide Y-mediated vasoconstriction in humans.The Journal of physiology · 2025Article
- Endothelial and exercise vasodilation are reduced in postmenopausal females with obesity versus lean and overweight.International journal of obesity (2005) · 2024Article
- Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Global REACH 2018: increased adrenergic restraint of blood flow preserves coupling of oxygen delivery and demand during exercise at high-altitude.The Journal of physiology · 2022Article
- Passive leg movement-induced vasodilation and exercise-induced sympathetic vasoconstriction.Autonomic neuroscience : basic & clinical · 2022Article
- ATP and acetylcholine interact to modulate vascular tone and αJournal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Global Reach 2018 Heightened α-Adrenergic Signaling Impairs Endothelial Function During Chronic Exposure to Hypobaric Hypoxia.Circulation research · 2020Article
- Healthy active older adults have enhanced KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- KThe Journal of physiology · 2020Article
- Mechanisms of sympathetic restraint in human skeletal muscle during exercise: role of α-adrenergic and nonadrenergic mechanisms.American journal of physiology. Heart and circulatory physiology · 2020Article
- Pathophysiology and Individualized Management of Vasovagal Syncope and Postural Tachycardia Syndrome in Children and Adolescents: An Update.Neuroscience bulletin · 2020Review
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Minimizing thermal damage to vascular nerves while drilling of calcified plaque.BMC research notes · 2019Article
- Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature.Physiological reports · 2019Article
- Preserved ability to blunt sympathetically-mediated vasoconstriction in exercising skeletal muscle of young obese humans.Physiological reports · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
key points'Functional sympatholysis' describes the ability of contracting skeletal muscle to attenuate sympathetic vasoconstriction, and is critical to ensure proper blood flow and oxygen delivery to metabolically active skeletal muscle. The signalling mechanism responsible for sympatholysis in healthy humans is unknown. Evidence from animal models has identified endothelium-derived hyperpolarization (EDH) as a potential mechanism capable of attenuating sympathetic vasoconstriction. In this study, increasing endothelium-dependent signalling during exercise significantly enhanced the ability of contracting skeletal muscle to attenuate sympathetic vasoconstriction in humans. This is the first study in humans to identify endothelium-dependent regulation of sympathetic vasoconstriction in contracting skeletal muscle, and specifically supports a role for EDH-like vasodilatory signalling. Impaired functional sympatholysis is a common feature of cardiovascular ageing, hypertension and heart failure, and thus identifying fundamental mechanisms responsible for sympatholysis is clinically relevant. ABSTRACT: Stimulation of α-adrenoceptors elicits vasoconstriction in resting skeletal muscle that is blunted during exercise in an intensity-dependent manner. In humans, the underlying mechanisms remain unclear. We tested the hypothesis that stimulating endothelium-dependent vasodilatory signalling will enhance the ability of contracting skeletal muscle to blunt α CONTROL: -31 ± 3% vs.; P < 0.05) and remained blunted during exercise (blockade: -15 ± 5 vs. CONTROL: -14 ± 5%). We conclude that stimulation of EDH-like vasodilatation can blunt α
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.