ArticleScientific reports2016
Novel Hydrogel Material as a Potential Embolic Agent in Embolization Treatments.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Advancements in hydrogel-based embolic agents: Categorized by therapeutic mechanisms.Cancer medicine · 2024Pooled it
- Interventional Embolization Under Multifactorial Coupling: Mechanisms of Embolic-Agent Distribution and Feasibility of Closed-Loop Automatic Injection.Annals of biomedical engineering · 2026Review
- An injectable and dual-crosslinked hydrogel for controlled and permanent vascular embolization.Bioactive materials · 2025Article
- A Single Institution Experience with a Shear-Thinning Conformable Embolic for Endovascular Embolization.Cardiovascular and interventional radiology · 2025Article
- OnyxGels (Basel, Switzerland) · 2024Review
- Photomodulated Extrusion as a Localized Endovascular Hydrogel Deposition Method.Advanced healthcare materials · 2023Article
- Material characterization of GPXFrontiers in bioengineering and biotechnology · 2023Article
- Photosensitive Hydrogel-Based Embolic Agent Treatment of Wide-Necked Aneurysms: Preliminary Animal Results.Gels (Basel, Switzerland) · 2022Article
- Bioactive-Tissue-Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Emerging Embolic Agents in Endovascular Embolization: An Overview.Progress in biomedical engineering (Bristol, England) · 2020Article
- Article
- Advances in Biomaterials and Technologies for Vascular Embolization.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- In Situ-Forming Polyamidoamine Dendrimer Hydrogels with Tunable Properties Prepared via Aza-Michael Addition Reaction.ACS applied materials & interfaces · 2017Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a novel graphene-oxide (GO) enhanced polymer hydrogel (GPH) as a promising embolic agent capable of treating cerebrovascular diseases and malignant tumors, using the trans-catheter arterial embolization (TAE) technique. Simply composed of GO and generation five poly(amidoamine) dendrimers (PAMAM-5), our rheology experiments reveal that GPH exhibits satisfactory mechanical strength, which resist the high pressures of blood flow. Subcutaneous experiments on Sprague-Dawley (SD) rats demonstrate the qualified biocompatibility of GPH. Finally, our in vivo experiments on New Zealand rabbits, which mix GPH with the X-ray absorbing contrast agent, Iohexol, reveal complete embolization of the artery. We also note that GPH shortens embolization time and exhibits low toxicity in follow-up experiments. Altogether, our study demonstrates that GPH has many advantages over the currently used embolic agents and has potential applications in clinical practice.
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