ArticleScientific reports2016
Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Impaired leptin A signaling disrupts hepatic lipid metabolism and growth in female medaka (Oryzias latipes).Fish physiology and biochemistry · 2026Article
- Histology of Liver Vascular-Biliary Tracts and Associated Exocrine Pancreas in Guppies (Poecilia reticulata) at Three Post-Hatch Ages.Anatomia, histologia, embryologia · 2026Article
- Baseline estrogenic activity in juvenile brown trout liver and primary hepatocytes: integrated molecular and immunohistochemical analysis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Identifying sex-linked metabolomic biomarkers in fish gonads after bacterial infection.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Evaluation of minimally invasive metabolomic methods for assessing the health of sturgeons.Scientific reports · 2025Article
- Sexual dimorphism in zebrafish liver proteins and implications for hepatic regeneration and diseases.Scientific reports · 2025Article
- Transcriptomic Divergence and Associated Markers Between Genomic Lineages of Silver Catfish (Ecology and evolution · 2025Article
- Season affects the estrogen system and the immune response of common carp.Fish physiology and biochemistry · 2024Article
- Theoretical Analysis and Expression Profiling of 17β-Hydroxysteroid Dehydrogenase Genes in Gonadal Development and Steroidogenesis of Leopard Coral Grouper (International journal of molecular sciences · 2024Article
- Sex-biased gene expression at single-cell resolution: cause and consequence of sexual dimorphism.Evolution letters · 2023Article
- Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.PLoS genetics · 2021Article
- Strain-Specific Liver Metabolite Profiles in Medaka.Metabolites · 2021Article
- Review
- Embryonic Onset of Sexually Dimorphic Heart Rates in the Viviparous Fish,Biomedicines · 2021Article
- Gene expression dynamics during rapid organismal diversification in African cichlid fishes.Nature ecology & evolution · 2021Article
- Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver.Cell death and differentiation · 2020Article
- Screening of Biomarkers Related to Ovarian Maturation and Spawning in Blunt Snout Bream (Megalobrama amblycephala) Based on Metabolomics and Transcriptomics.Marine biotechnology (New York, N.Y.) · 2020Article
- Improvement of the Pacific bluefin tuna (Thunnus orientalis) reference genome and development of male-specific DNA markers.Scientific reports · 2019Article
- Sex-Specific Co-expression Networks and Sex-Biased Gene Expression in the Salmonid Brook CharrG3 (Bethesda, Md.) · 2019Article
- Genomics of sex hormone receptor signaling in hepatic sexual dimorphism.Molecular and cellular endocrinology · 2018Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual dimorphism describes the features that discriminate between the two sexes at various biological levels. Especially, during the reproductive phase, the liver is one of the most sexually dimorphic organs, because of different metabolic demands between the two sexes. The liver is a key organ that plays fundamental roles in various physiological processes, including digestion, energetic metabolism, xenobiotic detoxification, biosynthesis of serum proteins, and also in endocrine or immune response. The sex-dimorphism of the liver is particularly obvious in oviparous animals, as the female liver is the main organ for the synthesis of oocyte constituents. In this work, we are interested in identifying molecular sexual dimorphism in the liver of adult medaka fish and their sex-variation in response to hepatotoxic exposures. By developing an integrative approach combining histology and different high-throughput omic investigations (metabolomics, proteomics and transcriptomics), we were able to globally depict the strong sexual dimorphism that concerns various cellular and molecular processes of hepatocytes comprising protein synthesis, amino acid, lipid and polysaccharide metabolism, along with steroidogenesis and detoxification. The results of this work imply noticeable repercussions on the biology of oviparous organisms environmentally exposed to chemical or toxin issues.
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