Evidence map›Paper›PMID 27561662›Full record

ReviewNeuropsychology review2016

Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review.

Breton M Asken, Molly J Sullan, Aliyah R Snyder, Zachary M Houck, Vaughn E Bryant, Loren P Hizel, Molly E McLaren, Duane E Dede, Michael S Jaffee, Steven T DeKosky and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychology review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  14. Brain, behavior, & immunity - health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Breton M AskenDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA. basken8@phhp.ufl.edu.
Molly J SullanDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Aliyah R SnyderDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Zachary M HouckDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Vaughn E BryantDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Loren P HizelDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Molly E McLarenDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Duane E DedeDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Michael S JaffeeDepartment of Neurology, University of Florida, Gainesville, FL, USA.
Steven T DeKoskyDepartment of Neurology, University of Florida, Gainesville, FL, USA.
Russell M BauerDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
University of Florida Health · USUniversity of Florida · US

Funding

Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7M
Working memory: a critical factor underlying alcohol reduction intervention responseF31AA024060 · NIAAA · UNIVERSITY OF FLORIDA · PI BRYANT, VAUGHN E · 2015 to 2017
$115k
NIAAA NIH HHS F31 AA024060NIA NIH HHS T32 AG020499
6 · The paper itself

Abstract

Chronic traumatic encephalopathy (CTE) is a neuropathologically defined disease reportedly linked to a history of repetitive brain trauma. As such, retired collision sport athletes are likely at heightened risk for developing CTE. Researchers have described distinct pathological features of CTE as well a wide range of clinical symptom presentations, recently termed traumatic encephalopathy syndrome (TES). These clinical symptoms are highly variable, non-specific to individuals described as having CTE pathology in case reports, and are often associated with many other factors. This review describes the cognitive, emotional, and behavioral changes associated with 1) developmental and demographic factors, 2) neurodevelopmental disorders, 3) normal aging, 4) adjusting to retirement, 5) drug and alcohol abuse, 6) surgeries and anesthesia, and 7) sleep difficulties, as well as the relationship between these factors and risk for developing dementia-related neurodegenerative disease. We discuss why some professional athletes may be particularly susceptible to many of these effects and the importance of choosing appropriate controls groups when designing research protocols. We conclude that these factors should be considered as modifiers predominantly of the clinical outcomes associated with repetitive brain trauma within a broader biopsychosocial framework when interpreting and attributing symptom development, though also note potential effects on neuropathological outcomes. Importantly, this could have significant treatment implications for improving quality of life.

Indexed as

Chronic Traumatic EncephalopathyAthletic InjuriesCognition DisordersHumansMental DisordersMood DisordersNeurodevelopmental DisordersRetirementBiopsychosocialBrain injuryChronic traumatic encephalopathyConcussionCTERepetitive brain trauma

Identifiers

PMID27561662
PMCPMC5507554
OpenAlexW2516884459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.