Evidence map›Paper›PMID 27561640›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2016

Perioperative inflammatory response in major fracture: do geriatric patients behave differently?

M Thaeter, M Knobe, M Vande Kerckhove, F Böhle, J Herold, E Verhaven, H-C Pape

Abstract read
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In one paragraph

Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Paradigm shift in geriatric fracture treatment.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019
    Review
  4. Systemic Bone Loss After Fracture.Clinical reviews in bone and mineral metabolism · 2018
    Article
  5. Focus on co-management in geriatric fracture care.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

M ThaeterHarald Tscherne Research Laboratory for Orthopaedic Trauma, Aachen University Medical Centre, Pauwelsst. 30, 52074, Aachen, Germany. mthaeter@ukaachen.de.
M KnobeHarald Tscherne Research Laboratory for Orthopaedic Trauma, Aachen University Medical Centre, Pauwelsst. 30, 52074, Aachen, Germany.
M Vande KerckhoveHarald Tscherne Research Laboratory for Orthopaedic Trauma, Aachen University Medical Centre, Pauwelsst. 30, 52074, Aachen, Germany.
F BöhleHarald Tscherne Research Laboratory for Orthopaedic Trauma, Aachen University Medical Centre, Pauwelsst. 30, 52074, Aachen, Germany.
J HeroldHarald Tscherne Research Laboratory for Orthopaedic Trauma, Aachen University Medical Centre, Pauwelsst. 30, 52074, Aachen, Germany.
E VerhavenDepartment of Orthopaedic Surgery, St. Nicolaus Hospital, Hufengasse 4, 4700, Eupen, Belgium.
H-C PapeHarald Tscherne Research Laboratory for Orthopaedic Trauma, Aachen University Medical Centre, Pauwelsst. 30, 52074, Aachen, Germany.
RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInterleukin-6 is a mainly proinflammatory interleukin and an indicator for the magnitude of surgery. The IL-6 serum concentration correlates with injury severity, the extent of tissue trauma and has negative impact on prognosis. To date it is unclear whether the immunologic changes assessed are age dependent. The aim of this study is to compare the surgical inflammatory response in different age groups.

methodsData were collected at a level-1 university trauma center in a prospective, consecutive cohort study. IL-6 levels were analyzed via ELISA from venous blood samples of cohorts of injuries with typical peak incidence: patients with unstable fractures of the spine (SP) for a middle-aged group and patients with fractures of the proximal femur (PF) for a geriatric group. Surgical treatment was performed using minimal-invasive instrumentation.

results25 patients in group SP (age: 51 years ± 20) and 16 patients in the group PF (age: 73 years ± 16) were analysed. Group PF showed higher baseline IL-6 concentrations. Surgical treatment was followed by a significant increase of IL-6 levels in both groups 4 and 24 h postoperatively. Concentration profiles were similar, but increase was significantly higher in the PF group 4 h after surgery.

conclusionBoth the operative treatment of fractures in a middle-aged (SP) and a geriatric group (PF) lead to significant increasing of IL-6 levels. In view of a comparative surgical burden, these data suggest that age may be a confounding factor for a surgery induced pro-inflammatory response in the early postoperative stage.

Indexed as

Geriatric AssessmentAgedAged, 80 and overBiomarkersFemaleFemoral FracturesFracture Fixation, InternalHumansInflammationInterleukin-6MaleMiddle AgedPatient SelectionPostoperative ComplicationsPrognosisProspective StudiesBiomarkersIL6 protein, humanInterleukin-6FractureGeriatricsInflammatory responseInterleukin-6 (IL-6)Surgical burdenTrauma

Identifiers

PMID27561640
OpenAlexW2511346063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.