ArticleNature communications2016
Mapping surface charge density of lipid bilayers by quantitative surface conductivity microscopy.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Development of scanning ion-conductance microscopy based tip-enhanced Raman spectroscopy in liquid environments.Nanotechnology · 2026Review
- Applications of Nanopipettes in Scanning Ion Conductance Microscopy for High-Spatial-Resolution Topographic Imaging and Sensing in Single Cells.ACS measurement science au · 2026Review
- Two-step formation of multilayered membrane pattern from living cells and probing its nanoscale physicochemical properties via nanopipette.Materials today. Bio · 2026Article
- Optical voltammetry of redox processes inside a nanohole with opto-iontronic microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Molecular Interplay Between Lipids, Cholesterol and Membrane Hydration Layer.Sub-cellular biochemistry · 2026Review
- A Look inside a Flexible Open-Source Scanning Electrochemical Probe Microscope.ACS electrochemistry · 2026Article
- Nanopipette-Based Probe Deciphering Nanoscale Charge Distribution of Graphene Layers Affecting Peptide Binding and Assembling.Analytical chemistry · 2025Article
- Super-resolution imaging with nanopipettes.Npj imaging · 2025Article
- Aromatic Anion Carrier via Self-Assembly with Imidazolium-Fused Aromatic Amphiphiles.Precision chemistry · 2025Article
- Negative memory capacitance and ionic filtering effects in asymmetric nanopores.Nature nanotechnology · 2025Article
- Single-Cell Analysis with Spatiotemporal Control of Local pH.ACS measurement science au · 2025Article
- Topological damping in an ultrafast giant cell.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Charge Mapping ofAnalytical chemistry · 2023Article
- Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors.Biosensors · 2023Article
- The New Era of High-Throughput Nanoelectrochemistry.Analytical chemistry · 2023Review
- Self-snapping hydrogel-based electroactive microchannels as nerve guidance conduits.Materials today. Bio · 2022Article
- Electrically controlling and optically observing the membrane potential of supported lipid bilayers.Biophysical journal · 2022Article
- Analytical challenges of glycosaminoglycans at biological interfaces.Analytical and bioanalytical chemistry · 2022Article
- Scanning Ion Conductance Microscopy.Chemical reviews · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local surface charge density of lipid membranes influences membrane-protein interactions leading to distinct functions in all living cells, and it is a vital parameter in understanding membrane-binding mechanisms, liposome design and drug delivery. Despite the significance, no method has so far been capable of mapping surface charge densities under physiologically relevant conditions. Here, we use a scanning nanopipette setup (scanning ion-conductance microscope) combined with a novel algorithm to investigate the surface conductivity near supported lipid bilayers, and we present a new approach, quantitative surface conductivity microscopy (QSCM), capable of mapping surface charge density with high-quantitative precision and nanoscale resolution. The method is validated through an extensive theoretical analysis of the ionic current at the nanopipette tip, and we demonstrate the capacity of QSCM by mapping the surface charge density of model cationic, anionic and zwitterionic lipids with results accurately matching theoretical values.
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Registered trials
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