ArticleNeurochemical research2016
Effects of Etomidate on GABAergic and Glutamatergic Transmission in Rat Thalamocortical Slices.
Article in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Dexmedetomidine Reduces Presynaptic γ-Aminobutyric Acid Release and Prolongs Postsynaptic Responses in Layer 5 Pyramidal Neurons in the Primary Somatosensory Cortex ofInternational journal of molecular sciences · 2025Article
- Glutamatergic neurons in paraventricular nucleus of the thalamus regulate the recovery from isoflurane anesthesia.BMC anesthesiology · 2022Article
- Electroencephalographic dynamics of etomidate-induced loss of consciousness.BMC anesthesiology · 2021Observational
- Dopaminergic D1 receptors in the nucleus basalis modulate recovery from propofol anesthesia in rats.Iranian journal of basic medical sciences · 2020Article
- Effects of ketamine on voltage-gated sodium channels in the barrel cortex and the ventral posteromedial nucleus slices of rats.Neuroreport · 2019Article
- Comparison of αβδ and αβγ GABAPharmacological research · 2018Review
- Xylazine Regulates the Release of Glycine and Aspartic Acid in Rat Brain.Journal of veterinary research · 2018Article
- Ketamine attenuates the glutamatergic neurotransmission in the ventral posteromedial nucleus slices of rats.BMC anesthesiology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although accumulative evidence indicates that the thalamocortical system is an important target for general anesthetics, the underlying mechanisms of anesthetic action on thalamocortical neurotransmission are not fully understood. The aim of the study is to explore the action of etomidate on glutamatergic and GABAergic transmission in rat thalamocortical slices by using whole cell patch-clamp recording. We found that etomidate mainly prolonged the decay time of spontaneous GABAergic inhibitory postsynaptic currents (sIPSCs), without changing the frequency. Furthermore, etomidate not only prolonged the decay time of miniature inhibitory postsynaptic currents (mIPSCs) but also increased the amplitude. On the other hand, etomidate significantly decreased the frequency of spontaneous glutamatergic excitatory postsynaptic currents (sEPSCs), without altering the amplitude or decay time in the absence of bicuculline. When GABA
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