ArticleScientific reports2016
Expression of segment polarity genes in brachiopods supports a non-segmental ancestral role of engrailed for bilaterians.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- An Increase in Animal Diversity was Facilitated by Ecologically-Driven Brain Complexity Throughout the Cambrian.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Cell fate specification modes shape transcriptome evolution in the highly conserved spiral cleavage.EMBO reports · 2025Article
- Embryogenesis in Myrmicine Ants Combines Features of Short Germ-Band Development With a Progressive Mode of Segmentation.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.BMC biology · 2024Article
- Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core.International journal of molecular sciences · 2022Article
- Brachiopod and mollusc biomineralisation is a conserved process that was lost in the phoronid-bryozoan stem lineage.EvoDevo · 2022Article
- The Nasonia pair-rule gene regulatory network retains its function over 300 million years of evolution.Development (Cambridge, England) · 2022Article
- The evolution of the metazoan Toll receptor family and its expression during protostome development.BMC ecology and evolution · 2021Article
- Molecular and morphological analysis of the developing nemertean brain indicates convergent evolution of complex brains in Spiralia.BMC biology · 2021Article
- Article
- FGF signaling acts on different levels of mesoderm development within Spiralia.Development (Cambridge, England) · 2021Article
- Embryonic expression of priapulid Wnt genes.Development genes and evolution · 2019Article
- Article
- Convergent evolution of bilaterian nerve cords.Nature · 2018Article
- An ancient FMRFamide-related peptide-receptor pair induces defence behaviour in a brachiopod larva.Open biology · 2017Article
- Possible co-option ofBiology letters · 2017Article
- Article
- Ancestral and novel roles of Pax family genes in mollusks.BMC evolutionary biology · 2017Article
- Clustered brachiopod Hox genes are not expressed collinearly and are associated with lophotrochozoan novelties.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Gene Expression Patterns in Brachiopod Larvae Refute the "Brachiopod-Fold" Hypothesis.Frontiers in cell and developmental biology · 2017Article
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Abstract
The diverse and complex developmental mechanisms of segmentation have been more thoroughly studied in arthropods, vertebrates and annelids-distantly related animals considered to be segmented. Far less is known about the role of "segmentation genes" in organisms that lack a segmented body. Here we investigate the expression of the arthropod segment polarity genes engrailed, wnt1 and hedgehog in the development of brachiopods-marine invertebrates without a subdivided trunk but closely related to the segmented annelids. We found that a stripe of engrailed expression demarcates the ectodermal boundary that delimits the anterior region of Terebratalia transversa and Novocrania anomala embryos. In T. transversa, this engrailed domain is abutted by a stripe of wnt1 expression in a pattern similar to the parasegment boundaries of insects-except for the expression of hedgehog, which is restricted to endodermal tissues of the brachiopod embryos. We found that pax6 and pax2/5/8, putative regulators of engrailed, also demarcate the anterior boundary in the two species, indicating these genes might be involved in the anterior patterning of brachiopod larvae. In a comparative phylogenetic context, these findings suggest that bilaterians might share an ancestral, non-segmental domain of engrailed expression during early embryogenesis.
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