ArticleMolecular and cellular endocrinology2016
Evaluation of in vivo bioactivities of recombinant hypo- (FSH
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Molecular and cellular endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03868202 (Follicle Stimulating Hormone), which is not on this map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Follicle Stimulating Hormone (FSH) Glycosylation in Women: Effect of Estradiol
Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Single-chain human Follicle-stimulating hormone promotes ovarian and testicular growth and improves pregnancy performance in mice.PloS one · 2026Article
- Hypo-glycosylated FSH enhances the ovarian microenvironment for follicular development compared to fully glycosylated FSH.Cell communication and signaling : CCS · 2025Article
- Identification of FSH-regulated and estrous stage-specific transcriptional networks in mouse ovaries.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Oocyte quality is enhanced by hypoglycosylated FSH through increased cell-to-cell interaction during mouse follicle development.Development (Cambridge, England) · 2023Article
- Differential effects of follicle-stimulating hormone glycoforms on the transcriptome profile of cultured rat granulosa cells as disclosed by RNA-seq.bioRxiv : the preprint server for biology · 2023Article
- RNA-seq analysis identifies age-dependent changes in expression of mRNAs - encoding N-glycosylation pathway enzymes in mouse gonadotropes.Molecular and cellular endocrinology · 2023Article
- Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?International journal of molecular sciences · 2023Review
- Follicle-Stimulating Hormone Glycosylation Variants Distinctly Modulate Pre-antral Follicle Growth and Survival.Endocrinology · 2022Article
- Human FSH Glycoform α-Subunit AsparagineFrontiers in endocrinology · 2022Article
- Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling.Human reproduction (Oxford, England) · 2021Article
- Recent advances in understanding gonadotropin signaling.Faculty reviews · 2021Review
- New Human Follitropin Preparations: How Glycan Structural Differences May Affect Biochemical and Biological Function and Clinical Effect.Frontiers in endocrinology · 2021Review
- Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling.Frontiers in endocrinology · 2021Article
- In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables†.Biology of reproduction · 2020Review
- Bioactivity of recombinant hFSH glycosylation variants in primary cultures of porcine granulosa cells.Molecular and cellular endocrinology · 2020Article
- Use of Biosimilar Follicle-Stimulating Hormone in Asthenozoospermic Infertile Patients: A Multicentric Study.Journal of clinical medicine · 2020Article
- In Vitro Impact of FSH Glycosylation Variants on FSH Receptor-stimulated Signal Transduction and Functional Selectivity.Journal of the Endocrine Society · 2020Article
- FSH for the Treatment of Male Infertility.International journal of molecular sciences · 2020Review
- Recombinant FSH glycoforms are bioactive in mouse preantral ovarian follicles.Reproduction (Cambridge, England) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Huizhen WangDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Jacob MayDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Viktor ButnevDepartment of Biological Sciences, Wichita State University, Wichita, KS 67260, USA.
Bin ShuaiDepartment of Biological Sciences, Wichita State University, Wichita, KS 67260, USA.
Jeffrey V MayDepartment of Biological Sciences, Wichita State University, Wichita, KS 67260, USA.
George R BousfieldDepartment of Biological Sciences, Wichita State University, Wichita, KS 67260, USA.
T Rajendra KumarDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA; Center for Reproductive Sciences, Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA; Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS 66160, USA; Division of Reproductive Sciences, Department of Obstetrics & Gynecology, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: raj.kumar@ucdenver.edu.
Wichita State University · USUniversity of Kansas Medical Center · USUniversity of Colorado Denver · US
Funding
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0MThe Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI CHITTIBABU GUDA · 2009 to 2026
$25.9MChemoprevention of Pituitary Gondadotrope TumorsR01CA166557 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KUMAR, T. RAJENDRA · 2013 to 2017
$1.6MNCI NIH HHS R01 CA166557NIA NIH HHS P01 AG029531NIGMS NIH HHS P20 GM103418
Abstract
The hormone - specific FSHβ subunit of the human FSH heterodimer consists of N-linked glycans at Asn
Indexed as
AnimalsBlotting, WesternCyclic AMP Response Element-Binding ProteinFemaleFollicle Stimulating Hormone, beta SubunitFollicle Stimulating Hormone, HumanGene Expression RegulationGlycosylationHumansMaleMice, KnockoutOvaryPhosphorylationReal-Time Polymerase Chain ReactionRecombinant ProteinsSignal TransductionCyclic AMP Response Element-Binding ProteinFollicle Stimulating Hormone, beta SubunitFollicle Stimulating Hormone, HumanRecombinant ProteinsFSH-responsive genesN-glycosylationOvaryPharmacological rescueTestis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT03868202ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.