Evidence map›Paper›PMID 27561093›Full record

ArticlePloS one2016

Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study.

Eija Nukarinen, Outi Lindström, Krista Kuuliala, Leena Kylänpää, Ville Pettilä, Pauli Puolakkainen, Antti Kuuliala, Mari Hämäläinen, Eeva Moilanen, Heikki Repo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Eija NukarinenDepartment of Perioperative, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Outi LindströmDepartment of GI Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Krista KuulialaDepartment of Bacteriology and Immunology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Leena KylänpääDepartment of GI Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Ville PettiläDepartment of Perioperative, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Pauli PuolakkainenDepartment of GI Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Antti KuulialaDepartment of Bacteriology and Immunology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mari HämäläinenThe Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland.
Eeva MoilanenThe Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland.
Heikki RepoDepartment of Bacteriology and Immunology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Johanna HästbackaDepartment of Perioperative, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Helsinki University Hospital · FIUniversity of Helsinki · FITampere University · FITampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSeveral biomarkers for early detection of severe acute pancreatitis (SAP) have been presented. Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are released early in inflammation. We aimed to assess levels of MMP-7, -8, -9 and TIMP-1 in acute pancreatitis (AP) and explore their ability to detect disease severity. Our second aim was to find an association between MMPs, TIMP and creatinine.

methodsWe collected plasma samples for MMP-7, -8, -9 and TIMP-1 analyses from 176 patients presenting within 96 h from onset of acute pancreatitis (AP) symptoms. We used samples from 32 control subjects as comparison. The revised Atlanta Classification was utilised to assess severity of disease. Receiver operating characteristic curve analysis and Spearman´s Rho-test were utilised for statistical calculations.

resultsCompared with controls, patients showed higher levels of all studied markers. MMP-8 was higher in moderately severe AP than in mild AP (p = 0.005) and MMP-8, -9 and TIMP-1 were higher in severe than in mild AP (p<0.001, p = 0.005 and p = 0.019). MMP-8 detected SAP with an AUC of 0.939 [95% CI 0.894-0.984], LR+ 9.03 [5.30-15.39]. MMP-8, -9 and TIMP-1 failed to discern moderately severe AP from SAP. MMP-7 was not different between patient groups. MMP-7 and TIMP-1 correlated weakly with creatinine (Rho = 0.221 and 0.243). MMP-8 might be a useful biomarker in early detection of SAP.

Indexed as

AdultAgedAged, 80 and overBiomarkersCase-Control StudiesCohort StudiesFemaleHumansInflammationMaleMatrix Metalloproteinase 7Matrix Metalloproteinase 8Matrix Metalloproteinase 9Middle AgedModels, StatisticalPancreatitis, Acute NecrotizingBiomarkersMatrix Metalloproteinase 7Matrix Metalloproteinase 8Matrix Metalloproteinase 9MMP7 protein, humanMMP8 protein, humanMMP9 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1

Identifiers

PMID27561093
PMCPMC4999158
OpenAlexW2515898364

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.