ArticleScientific reports2016
Whole Genome Sequencing Identifies a Missense Mutation in HES7 Associated with Short Tails in Asian Domestic Cats.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- The late arrival of domestic cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism.Cell genomics · 2026Article
- Article
- Article
- Chromosome-scale assembly with improved annotation provides insights into breed-wide genomic structure and diversity in domestic cats.Journal of advanced research · 2025Article
- Pig tail length is associated with the prevalence of tail malformations but not with inflammation of the tail.BMC veterinary research · 2025Article
- Genome-Wide Association Study Reveals Single Nucleotide Polymorphisms Associated with Tail Length and Tail Kinks in Piglets.Veterinary sciences · 2025Article
- Emerging Human Health Problems Caused by Pathogenic and Immuno-activating Fungi.Current topics in microbiology and immunology · 2025Review
- Article
- A Single-Cell Atlas of an Early Mongolian Sheep Embryo.Veterinary sciences · 2023Article
- Fine-mapping and identification of candidate causal genes for tail length in the Merinolandschaf breed.Communications biology · 2022Article
- Development and Application of a High-Resolution Melting Analysis with Unlabeled Probes for the Screening of Short-Tailed SheepAnimals : an open access journal from MDPI · 2022Article
- Article
- Patterns of allele frequency differences among domestic cat breeds assessed by a 63K SNP array.PloS one · 2021Article
- Maternal and direct genetic parameters for tail length, tail lesions, and growth traits in pigs.Journal of animal science · 2021Article
- Two linked TBXT (brachyury) gene polymorphisms are associated with the tailless phenotype in fat-rumped sheep.Animal genetics · 2019Article
- Identification and quantification of domestic feline cytochrome P450 transcriptome across multiple tissues.Journal of veterinary pharmacology and therapeutics · 2019Article
- Tail reduction process during human embryonic development.Journal of anatomy · 2018Article
- Whole Genome Sequencing of Hulunbuir Short-Tailed Sheep for Identifying Candidate Genes Related to the Short-Tail Phenotype.G3 (Bethesda, Md.) · 2018Article
- Article
- The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domestic cats exhibit abundant variations in tail morphology and serve as an excellent model to study the development and evolution of vertebrate tails. Cats with shortened and kinked tails were first recorded in the Malayan archipelago by Charles Darwin in 1868 and remain quite common today in Southeast and East Asia. To elucidate the genetic basis of short tails in Asian cats, we built a pedigree of 13 cats segregating at the trait with a founder from southern China and performed linkage mapping based on whole genome sequencing data from the pedigree. The short-tailed trait was mapped to a 5.6 Mb region of Chr E1, within which the substitution c. 5T > C in the somite segmentation-related gene HES7 was identified as the causal mutation resulting in a missense change (p.V2A). Validation in 245 unrelated cats confirmed the correlation between HES7-c. 5T > C and Chinese short-tailed feral cats as well as the Japanese Bobtail breed, indicating a common genetic basis of the two. In addition, some of our sampled kinked-tailed cats could not be explained by either HES7 or the Manx-related T-box, suggesting at least three independent events in the evolution of domestic cats giving rise to short-tailed traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.