Evidence map›Paper›PMID 27560963›Full record

ArticlePloS one2016

Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study.

Tine D Clausen, Thomas Bergholt, Olivier Bouaziz, Magnus Arpi, Frank Eriksson, Steen Rasmussen, Niels Keiding, Ellen C Løkkegaard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  18. New insights into the treatment of acute otitis media.Expert review of anti-infective therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tine D ClausenDepartment of Gynecology and Obstetrics, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark.ORCID http://orcid.org/0000-0001-5585-2153
Thomas BergholtDepartment of Obstetrics, Rigshospitalet, University of Copenhagen, Copenhagen OE, Denmark.
Olivier BouazizDepartment of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen K, Denmark.
Magnus ArpiDepartment of Clinical Microbiology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Frank ErikssonDepartment of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen K, Denmark.
Steen RasmussenDepartment of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
Niels KeidingDepartment of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen K, Denmark.
Ellen C LøkkegaardDepartment of Gynecology and Obstetrics, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark.
University of Copenhagen · DKDélégation Paris 5 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies link antibiotic treatment and delivery by cesarean section with increased risk of chronic diseases through changes of the gut-microbiota. We aimed to evaluate the association of broad-spectrum antibiotic treatment during the first two years of life with subsequent onset of childhood type 1 diabetes and the potential effect-modification by mode of delivery. MATERIALS AND

methodsA Danish nationwide cohort study including all singletons born during 1997-2010. End of follow-up by December 2012. Four national registers provided information on antibiotic redemptions, outcome and confounders. Redemptions of antibiotic prescriptions during the first two years of life was classified into narrow-spectrum or broad-spectrum antibiotics. Children were followed from age two to fourteen, both inclusive. The risk of type 1 diabetes with onset before the age of 15 years was assessed by Cox regression. A total of 858,201 singletons contributed 5,906,069 person-years, during which 1,503 children developed type 1 diabetes.

resultsRedemption of broad-spectrum antibiotics during the first two years of life was associated with an increased rate of type 1 diabetes during the following 13 years of life (HR 1.13; 95% CI 1.02 to 1.25), however, the rate was modified by mode of delivery. Broad-spectrum antibiotics were associated with an increased rate of type 1 diabetes in children delivered by either intrapartum cesarean section (HR 1.70; 95% CI 1.15 to 2.51) or prelabor cesarean section (HR 1.63; 95% CI 1.11 to 2.39), but not in vaginally delivered children. Number needed to harm was 433 and 562, respectively. The association with broad-spectrum antibiotics was not modified by parity, genetic predisposition or maternal redemption of antibiotics during pregnancy or lactation.

conclusionsRedemption of broad-spectrum antibiotics during infancy is associated with an increased risk of childhood type 1 diabetes in children delivered by cesarean section.

Indexed as

AdolescentAnti-Bacterial AgentsCesarean SectionChildChild, PreschoolCohort StudiesDelivery, ObstetricDenmarkDiabetes Mellitus, Type 1FemaleHumansMalePregnancyProportional Hazards ModelsRegistriesAnti-Bacterial Agents

Identifiers

PMID27560963
PMCPMC4999141
OpenAlexW2512818000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.