Evidence map›Paper›PMID 27560936›Full record

ArticlePLoS pathogens2016

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions.

Alison L Hill, Daniel I S Rosenbloom, Janet D Siliciano, Robert F Siliciano

Abstract readComment
In one paragraph

Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Phylogenetic approach to recover integration dates of latent HIV sequences within-host.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  9. Modeling HIV persistence and cure studies.Current opinion in HIV and AIDS · 2018
    Review
  10. Article
  11. Article
  12. Article
  13. Modeling Kick-Kill Strategies toward HIV Cure.Frontiers in immunology · 2017
    Review
  14. Article
  15. Article
  16. Mathematical Models of HIV Latency.Current topics in microbiology and immunology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alison L HillProgram for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.ORCID 0000-0002-6583-3623
Daniel I S RosenbloomDepartment of Biomedical Informatics, Columbia University Medical Center, New York, New York, United States of America.
Janet D SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Using NK Cells to eliminate the latent HIV reservoirU19AI096113 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LUCIW, PAUL · 2011 to 2015
$39.5M
Viral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHACKER, TIMOTHY W · 2011 to 2015
$29.5M
Training in Biomedical Informatics at Columbia UniversityT15LM007079 · NLM · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NOEMIE ELHADAD, GEORGE M HRIPCSAK · 1992 to 2026
$28.9M
LATENT VIRAL RESERVOIRS IN HIV1 INFECTIONR01AI043222 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SILICIANO, ROBERT F · 1998 to 2013
$3.5M
Quantification and prediction of treatment efficacy for HIV cure strategiesDP5OD019851 · OD · JOHNS HOPKINS UNIVERSITY · PI HILL, ALISON LYNN · 2014 to 2018
$2.1M
Uncovering Evolutionary History using the Topology of Genomic Data with Applications to HIVR01GM117591 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RABADAN, RAUL · 2015 to 2018
$1.3M
NIAID NIH HHS P30 AI060354NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI043222NIAID NIH HHS U19 AI096109NIAID NIH HHS U19 AI096113NIGMS NIH HHS R01 GM117591NIH AI096113NIH P30AI060354NIH P30AI094189NIH R01AI043222NIH R01GM117591NIH T15LM007079NIH U19AI096109NIH HHS DP5 OD019851NLM NIH HHS T15 LM007079
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HIV-1Virus LatencyDrug ResistanceGenetic Variation

Identifiers

PMID27560936
PMCPMC4999146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.