ArticleThe Journal of comparative neurology2017
Anatomical characterization of subcortical descending projections to the inferior colliculus in mouse.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Circuit architecture and axonal branching in the efferent auditory system.Hearing research · 2026Review
- Noncanonical short-latency auditory pathway directly activates deep cortical layers.Nature communications · 2025Article
- The neural circuit mechanism for auditory responses in the mediodorsal thalamic nucleus of awake mice.Communications biology · 2025Article
- Descending projections to the auditory midbrain: evolutionary considerations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Diverse functions of the auditory cortico-collicular pathway.Hearing research · 2022Review
- Does hearing loss lead to dementia? A review of the literature.Hearing research · 2021Review
- 5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression.Frontiers in neural circuits · 2021Article
- Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections.Frontiers in neural circuits · 2020Review
- The Inferior Colliculus in Alcoholism and Beyond.Frontiers in systems neuroscience · 2020Review
- Article
- Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus.Frontiers in cellular neuroscience · 2019Article
- Neuronal Organization in the Inferior Colliculus Revisited with Cell-Type-Dependent Monosynaptic Tracing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The distribution of calbindin-D28k, parvalbumin, and calretinin immunoreactivity in the inferior colliculus of circling mouse.Anatomy & cell biology · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Descending projections from the thalamus and related structures to the midbrain are evolutionarily highly conserved. However, the basic organization of this auditory thalamotectal pathway has not yet been characterized. The purpose of this study was to obtain a better understanding of the anatomical and neurochemical features of this pathway. Analysis of the distributions of retrogradely labeled cells after focal injections of retrograde tracer into the inferior colliculus (IC) of the mouse revealed that most of the subcortical descending projections originated in the brachium of the IC and the paralaminar portions of the auditory thalamus. In addition, the vast majority of thalamotectal cells were found to be negative for the calcium-binding proteins calbindin, parvalbumin, or calretinin. Using two different strains of GAD-GFP mice, as well as immunostaining for GABA, we found that a subset of neurons in the brachium of the IC is GABAergic, suggesting that part of this descending pathway is inhibitory. Finally, dual retrograde injections into the IC and amygdala plus corpus striatum as well into the IC and auditory cortex did not reveal any double labeling. These data suggest that the thalamocollicular pathway comprises a unique population of thalamic neurons that do not contain typical calcium-binding proteins and do not project to other paralaminar thalamic forebrain targets, and that a previously undescribed descending GABAergic pathway emanates from the brachium of the IC. J. Comp. Neurol. 525:885-900, 2017. © 2016 Wiley Periodicals, Inc.
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