Evidence map›Paper›PMID 27560601›Full record

ReviewThe Journal of comparative neurology2017

Stem and progenitor cells of the mammalian olfactory epithelium: Taking poietic license.

James E Schwob, Woochan Jang, Eric H Holbrook, Brian Lin, Daniel B Herrick, Jesse N Peterson, Julie Hewitt Coleman

Abstract readReview
In one paragraph

Review in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 2 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 2 syntheses or guidelines pooled it, 264 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
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  7. Review
  8. Article
  9. Therapeutic Effects ofLife (Basel, Switzerland) · 2026
    Article
  10. Article
  11. Review
  12. Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026
    Article
  13. Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  14. Article
  15. Review
  16. Article
  17. Olfactory models as a platform for neuroscience research.Frontiers in cellular neuroscience · 2026
    Review
  18. Article
  19. Article
  20. Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

James E SchwobDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, 02132.
Woochan JangDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, 02132.
Eric H HolbrookDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, 02132.
Brian LinDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, 02132.ORCID http://orcid.org/0000-0002-8851-3534
Daniel B HerrickDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, 02132.
Jesse N PetersonDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, 02132.
Julie Hewitt ColemanDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, 02132.
Tufts University · US

Funding

REGULATION OF NEUROGENESIS IN OLFACTORY EPITHELIUMR01DC002167 · NIDCD · UPSTATE MEDICAL UNIVERSITY · PI SCHWOB, JAMES E. · 1994 to 2016
$5.2M
AGE-RELATED OLFACTORY LOSS: MECHANISMS AND TREATMENT OPTIONSR01DC014217 · NIDCD · TUFTS UNIVERSITY BOSTON · PI SCHWOB, JAMES E. · 2014 to 2018
$3.2M
The regulation of p63 expression and activation to multipotency in HBCs of the olF30DC013962 · NIDCD · TUFTS UNIVERSITY BOSTON · PI HERRICK, DANIEL · 2014 to 2018
$193k
Olfactory Stem and Progenitor Cell PlasticityF31DC014637 · NIDCD · TUFTS UNIVERSITY BOSTON · PI LIN, BRIAN · 2015 to 2016
$72k
Spatial regulation of olfactory receptor expression and neuronal identity during olfactory neurogenesisF31DC014398 · NIDCD · TUFTS UNIVERSITY BOSTON · PI COLEMAN, JULIE · 2015 to 2016
$53k
NIDCD NIH HHS F30 DC013962NIDCD NIH HHS F31 DC014398NIDCD NIH HHS F31 DC014637NIDCD NIH HHS R01 DC002167NIDCD NIH HHS R01 DC014217
6 · The paper itself

Abstract

The capacity of the olfactory epithelium (OE) for lifelong neurogenesis and regeneration depends on the persistence of neurocompetent stem cells, which self-renew as well as generating all of the cell types found within the nasal epithelium. This Review focuses on the types of stem and progenitor cells in the epithelium and their regulation. Both horizontal basal cells (HBCs) and some among the population of globose basal cells (GBCs) are stem cells, but the two types plays vastly different roles. The GBC population includes the basal cells that proliferate in the uninjured OE and is heterogeneous with respect to transcription factor expression. From upstream in the hierarchy to downstream, GBCs encompass 1) Sox2

Indexed as

AnimalsHumansNeural Stem CellsOlfactory Mucosaactive stem cellagingdedifferentiationglobose basal cellhorizontal basal cellneurogenesisp63reserve stem cell

Identifiers

PMID27560601
PMCPMC5805156
OpenAlexW2512311410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.