ArticleEndocrinology2016
Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice.
Open access · bronzeAbstract read
In one paragraph
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- A Systematic Review of the Epidemiologic Literature Assessing Health Outcomes in Populations Living near Oil and Natural Gas Operations: Study Quality and Future Recommendations.International journal of environmental research and public health · 2019Pooled it
- Exploring the endocrine activity of air pollutants associated with unconventional oil and gas extraction.Environmental health : a global access science source · 2018Pooled it
- Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.The Journal of reproduction and development · 2026Review
- Pathways for Potential Exposure to Onshore Oil and Gas Wastewater: What We Need to Know to Protect Human Health.GeoHealth · 2025Review
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Impact of developmental exposures to endocrine-disrupting chemicals on pituitary gland reproductive function.Reproduction (Cambridge, England) · 2024Review
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Evidence for reproductive health effects following exposure to hydraulic fracturing chemical mixtures.Reproduction (Cambridge, England) · 2024Review
- Transcriptome profiling reveals superovulation with the gonadotropin-releasing hormone agonist trigger impaired embryo implantation in mice.Frontiers in endocrinology · 2024Article
- The regulation of endocrine-disrupting chemicals to minimize their impact on health.Nature reviews. Endocrinology · 2023Review
- Associations between occurrence of birth defects and hydraulic fracturing activities in Barnett shale region, Texas.Heliyon · 2023Article
- Congenital anomalies associated with oil and gas development and resource extraction: a population-based retrospective cohort study in Texas.Journal of exposure science & environmental epidemiology · 2023Article
- Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice.Journal of immunotoxicology · 2021Article
- REPRODUCTIVE TOXICOLOGY: Effects of chemical mixtures on the ovary.Reproduction (Cambridge, England) · 2021Review
- Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.Endocrine reviews · 2021Review
- Endocrine disrupting activities and geochemistry of water resources associated with unconventional oil and gas activity.The Science of the total environment · 2020Article
- Developmental exposure to a mixture of unconventional oil and gas chemicals: A review of experimental effects on adult health, behavior, and disease.Molecular and cellular endocrinology · 2020Review
- Developmental exposure to chemicals associated with unconventional oil and gas extraction alters immune homeostasis and viral immunity of the amphibian Xenopus.The Science of the total environment · 2019Article
- Impact of upstream oil extraction and environmental public health: A review of the evidence.The Science of the total environment · 2019Review
- Developmental Exposure to a Mixture of Unconventional Oil and Gas Chemicals Increased Risk-Taking Behavior, Activity and Energy Expenditure in Aged Female Mice After a Metabolic Challenge.Frontiers in endocrinology · 2019Article
- Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice.Frontiers in endocrinology · 2019Article
- Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health Threat.Frontiers in endocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 1 country.
Christopher D KassotisNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
John J BromfieldNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
Kara C KlempNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
Chun-Xia MengNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
Andrew WolfeNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
R Thomas ZoellerNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
Victoria D BaliseNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
Chiamaka J IsiguzoNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
Donald E TillittNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
Susan C NagelNicholas School of the Environment (C.D.K.), Duke University, Durham, North Carolina 27708; Department of Animal Sciences (J.J.B.) and D. H. Barron Reproductive and Perinatal Biology Research Program (J.J.B.), University of Florida, Gainesville, Florida 32611; Department of Obstetrics, Gynecology and Women's Health (K.C.K., C.-X.M.,V.D.B., C.J.I., S.C.N.) and Division of Biological Sciences (V.D.B., S.C.N.), University of Missouri, Columbia, Missouri 65211; Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Biology (RTZ), University of Massachusetts Amherst, Amherst, Massachusetts 01003; and United States Geological Survey (D.E.T.), Columbia Environmental Research Center, Columbia, Missouri 65201.
University of Missouri Health System · USUniversity of Missouri · USColumbia Environmental Research CenterDuke University · USJohns Hopkins University · USUniversity of Florida · USUniversity of Massachusetts Amherst · US
Funding
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2013 to 2017
$9.7MAbstract
Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly used hydraulic fracturing chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors in a human endometrial cancer cell reporter gene assay and that mixtures can behave synergistically, additively, or antagonistically on these receptors. In the current study, pregnant female C57Bl/6 dams were exposed to a mixture of 23 commonly used unconventional oil and gas chemicals at approximately 3, 30, 300, and 3000 μg/kg·d, flutamide at 50 mg/kg·d, or a 0.2% ethanol control vehicle via their drinking water from gestational day 11 through birth. This prenatal exposure to oil and gas operation chemicals suppressed pituitary hormone concentrations across experimental groups (prolactin, LH, FSH, and others), increased body weights, altered uterine and ovary weights, increased heart weights and collagen deposition, disrupted folliculogenesis, and other adverse health effects. This work suggests potential adverse developmental and reproductive health outcomes in humans and animals exposed to these oil and gas operation chemicals, with adverse outcomes observed even in the lowest dose group tested, equivalent to concentrations reported in drinking water sources. These endpoints suggest potential impacts on fertility, as previously observed in the male siblings, which require careful assessment in future studies.
Indexed as
Hydraulic FrackingPrenatal Exposure Delayed EffectsAnimalsBody WeightEndocrine DisruptorsFemaleFertilityHeartMice, Inbred C57BLOrgan SizeOvaryPituitary HormonesPregnancyReproductionSexual MaturationEndocrine DisruptorsPituitary Hormones
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.