ArticlePloS one2016
Spatial Disassociation of Disrupted Functional Connectivity for the Default Mode Network in Patients with End-Stage Renal Disease.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- K-Means Clustering Algorithm-Based Functional Magnetic Resonance for Evaluation of Regular Hemodialysis on Brain Function of Patients with End-Stage Renal Disease.Computational and mathematical methods in medicine · 2022Article
- Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease.Frontiers in neuroscience · 2022Article
- Abnormal topological parameters in the default mode network in patients with impaired cognition undergoing maintenance hemodialysis.Frontiers in neurology · 2022Article
- Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline.Frontiers in medicine · 2021Article
- Structural and Functional Brain Changes in Hemodialysis Patients with End-Stage Renal Disease: DTI Analysis Results and ALFF Analysis Results.International journal of nephrology and renovascular disease · 2021Article
- How Do You Feel Now? The Salience Network Functional Connectivity in End-Stage Renal Disease.Frontiers in neuroscience · 2020Article
- Article
- Preferentially Disrupted Core Hubs Within the Default-Mode Network in Patients With End-Stage Renal Disease: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neurology · 2020Article
- Alterations of default mode functional connectivity in individuals with end-stage renal disease and mild cognitive impairment.BMC nephrology · 2019Article
- Association between abnormal thalamic metabolites and sleep disturbance in patients with end-stage renal disease.Metabolic brain disease · 2018Article
- Reduced White Matter Integrity With Cognitive Impairments in End Stage Renal Disease.Frontiers in psychiatry · 2018Article
- Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease.Neuropsychiatric disease and treatment · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the aberrant functional connectivity of the default mode network (DMN) in patients with end-stage renal disease (ESRD) and their clinical relevance. MATERIALS AND
methodsResting-state functional MRI data were collected from 31 patients with ESRD (24 men, 24-61 years) and 31 age- and gender-matched healthy controls (HCs, 21 men, 26-61years). A whole-brain seed-based functional connectivity analysis of these collected R-fMRI data was performed by locating the seeds in the posterior cingulate cortex (PCC) and ventromedial prefrontal cortex (vmPFC) to investigate the functional connectivity of the posterior and anterior DMN over the whole brain, respectively.
resultsCompared to the HCs, the patients exhibited significantly decreased functional connectivity with the PCC in the left middle temporal gyrus, the right anterior cingulate gyrus, and the bilateral medial superior frontal gyrus. For the vmPFC seed, only the right thalamus showed significantly decreased functional connectivity in the patients with ESRD compared to HCs. Interestingly, functional connectivity between the PCC and right medial superior frontal gyrus exhibited a significantly positive correlation with the hemoglobin level in the patients.
conclusionOur findings suggest a spatially specific disruption of functional connectivity in the DMN in patients with ESRD, thereby providing novel insights into our understanding of the neurophysiology mechanism that underlies the disease.
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