Evidence map›Paper›PMID 27559944›Full record

ArticleMedicine2016

18F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series.

Carole Eldin, Cléa Melenotte, Matthieu Million, Serge Cammilleri, Albert Sotto, Antoine Elsendoorn, Franck Thuny, Hubert Lepidi, France Roblot, Thierry Weitten and 10 more

Open access · goldAbstract read
In one paragraph

Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. A systematic review on the health outcomes associated with non-endocarditis manifestations of chronic Q fever.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Frontiers in immunology · 2025
    Article
  6. Article
  7. AcuteOpen forum infectious diseases · 2024
    Article
  8. Large-Vessel Vasculitis and Q Fever Correlation.European journal of case reports in internal medicine · 2024
    Article
  9. Microorganisms · 2023
    Article
  10. Article
  11. Vascular Complications inEJVES vascular forum · 2023
    Article
  12. Screening forJournal of veterinary research · 2022
    Article
  13. Article
  14. Molecular diagnosis ofAnnals of medicine · 2021
    Article
  15. Article
  16. Q Fever Osteoarticular Infection in Children.Emerging infectious diseases · 2020
    Article
  17. Review
  18. Persistent Coxiella burnetii cardiovascular infection on Bentall-De Bono prosthesis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  19. Q Fever in Southern California: a Case Series of 20 Patients from a VA Medical Center.The American journal of tropical medicine and hygiene · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 16 institutions in 3 countries.

Carole EldinUnité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculté de Médecine, CNRS UMR 7278, IRD 198, Aix-Marseille Université, 27 Bd Jean Moulin Service de médecine nucléaire, Hôpital de La Timone, Marseille Service de pathologies infectieuses et tropicales de l'hôpital de Nimes Service de médecine, Hôpital de Chatellerault Unité Nord Insuffisance cardiaque et valvulopathies (UNIV), Service de cardiologie CHU de Marseille, Hôpital Nord, AP-HM Chemin des Bourrely, Marseille Service de Pathologies infectieuses et tropicales, CHU de Poitiers Service de Médecine interne Hôpital de Gap Service de Médecine interne, hôpital Saint Luc, Lyon Service de Rhumatologie, Centre hospitalier de Vienne Service de Pathologies infectieuses et tropicales, CHU de Rouen Service de Pathologies infectieuses et tropicales, CHU de Tours Service de Médecine Interne, CH de Bourges Service de Médecine Interne, Hôpital Saint-Anne, Toulon Service mobile d'Infectiologie, CH Victor Dupouy, Argenteuil Service de Médecine interne, CHU de Nantes, France.
Cléa Melenotte
Matthieu Million
Serge Cammilleri
Albert Sotto
Antoine Elsendoorn
Franck Thuny
Hubert Lepidi
France Roblot
Thierry Weitten
Souad Assaad
Anissa Bouaziz
Claire Chapuzet
Guillaume Gras
Anne-Sophie Labussiere
Cécile Landais
Pascale Longuet
Agathe Masseau
Olivier Mundler
Didier Raoult
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes · FRCentre d'Investigation Clinique de Nantes · FRCentre Hospitalier Laennec · FRCentre Hospitalier Saint-Joseph Saint-Luc · FRCentre Hospitalier Universitaire de Nîmes · FRCentre Hospitalier Universitaire de Tours · FRÉcole Nationale Supérieure d'Art · FRHôpital de la Timone · FRHôpital d'Instruction des Armées Sainte-Anne · FRHôpital Nord · FRHôpital régional · CHInstitut de Médecine Tropicale du Service de Santé des Armées · FRInstitut de Recherche pour le Développement · FRUniversité Claude Bernard Lyon 1 · FRUniversité de Poitiers · FRUniversité de Rouen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because Q fever is mostly diagnosed serologically, localizing a persistent focus of Coxiella burnetii infection can be challenging. F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) could be an interesting tool in this context.We performed a retrospective study on patients diagnosed with C burnetii infection, who had undergone F-FDG PET/CT between 2009 and 2015. When positive F-FDG PET/CT results were obtained, we tried to determine if it changed the previous diagnosis by discovering or confirming a suspected focus of C burnetii infection.One hundred sixty-seven patients benefited from F-FDG PET/CT. The most frequent clinical subgroup before F-FDG PET/CT was patients with no identified focus of infection, despite high IgG1 serological titers (34%). For 59% (n = 99) of patients, a hypermetabolic focus was identified. For 62 patients (62.6%), the positive F-FDG PET/CT allowed the diagnosis to be changed. For 24 of them, (38.7%), a previously unsuspected focus of infection was discovered. Forty-two (42%) positive patients had more than 1 hypermetabolic focus. We observed 21 valvular foci, 34 vascular foci, and a high proportion of osteoarticular localizations (n = 21). We also observed lymphadenitis (n = 27), bone marrow hypermetabolism (n = 11), and 9 pulmonary localizations.We confirmed thatF-FDG PET/CT is a central tool in the diagnosis of C burnetii focalized persistent infection. We proposed new diagnostic scores for 2 main clinical entities identified using F-FDG PET/CT: osteoarticular persistent infections and lymphadenitis.

Indexed as

Positron Emission Tomography Computed TomographyAdultAgedBone Diseases, InfectiousCoxiella burnetiiEndocarditisFemaleFluorodeoxyglucose F18HumansImmunoglobulinsLymphadenitisMaleMiddle AgedPneumonia, BacterialProsthesis-Related InfectionsQ FeverFluorodeoxyglucose F18ImmunoglobulinsRadiopharmaceuticals

Identifiers

PMID27559944
PMCPMC5400310
OpenAlexW2507181715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.