ArticleThe Laryngoscope2017
Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography.
Article in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Method for retrospective, respiratory-gated, anatomical optical coherence tomography for airway wall elastography.Journal of biomedical optics · 2025Article
- Development of a Clinically Relevant Rabbit Model of Acute Laryngeal Injury.Laryngoscope investigative otolaryngology · 2025Article
- Preclinical Vocal Fold and Airway Injury Models: A Scoping Review.Laryngoscope investigative otolaryngology · 2025Review
- Establishment of a survival rabbit model for laryngotracheal stenosis: A prospective randomized study.Laryngoscope investigative otolaryngology · 2024Article
- Asphyxia caused by delayed subglottic stenosis after neck trauma.Forensic science, medicine, and pathology · 2021Article
- Quantitative Evaluation of Subglottic Stenosis Using Ultrashort Echo Time MRI in a Rabbit Model.The Laryngoscope · 2021Article
- Investigations on the potential of optical coherence tomography as an imaging tool for eustachian tube.Scientific reports · 2021Article
- Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography.Scientific reports · 2021Article
- Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis.Journal of biomedical optics · 2019Article
- Localized compliance measurement of the airway wall using anatomic optical coherence elastography.Optics express · 2019Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectives/hypothesisCurrent imaging modalities lack the necessary resolution to diagnose subglottic stenosis. The aim of this study was to use optical coherence tomography (OCT) to evaluate nascent subglottic mucosal injury and characterize mucosal thickness and structural changes using texture analysis in a simulated intubation rabbit model. STUDY
designProspective animal study in rabbits.
methodsThree-centimeter-long sections of endotracheal tubes (ETT) were endoscopically placed in the subglottis and proximal trachea of New Zealand White rabbits (n = 10) and secured via suture. OCT imaging and conventional endoscopic video was performed just prior to ETT segment placement (day 0), immediately after tube removal (day 7), and 1 week later (day 14). OCT images were analyzed for airway wall thickness and textural properties.
resultsEndoscopy and histology of intubated rabbits showed a range of normal to edematous tissue, which correlated with OCT images. The mean airway mucosal wall thickness measured using OCT was 336.4 μm (day 0), 391.3 μm (day 7), and 420.4 μm (day 14), with significant differences between day 0 and day 14 (P = .002). Significance was found for correlation and homogeneity texture features across all time points (P < .05).
conclusionsOCT is a minimally invasive endoscopic imaging modality capable of monitoring progression of subglottic mucosal injury. This study is the first to evaluate mucosal injury during simulated intubation using serial OCT imaging and texture analysis. OCT and texture analysis have the potential for early detection of subglottic mucosal injury, which could lead to better management of the neonatal airway and limit the progression to stenosis. LEVEL OF EVIDENCE: NA Laryngoscope, 127:64-69, 2017.
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