Evidence map›Paper›PMID 27559544›Full record

ArticleAutoimmune and infectious diseases : open access2016

Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania.

Muneer Abbas, Noureddine Berka, Mozna Khraiwesh, Ali Ramadan, Victor Apprey, Paulette Furbert-Harris, Thomas Quinn, Hassan Brim, Georgia Dunston

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autoimmune and infectious diseases : open access, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Muneer AbbasDepartment of Microbiology, Howard University, Washington, DC, USA.
Noureddine BerkaCalgary Laboratory Services, Tissue Typing Laboratory, Canada.
Mozna KhraiweshDivision of Experimental Therapeutics, Department of Drug Discovery, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ali RamadanDepartment of Pathology, Howard University Hospital, Washington, DC, USA.
Victor AppreyDepartment of Microbiology, Howard University, Washington, DC, USA; Department of Community Health and Family Medicine, Howard University, Washington DC, USA.
Paulette Furbert-HarrisDepartment of Microbiology, Howard University, Washington, DC, USA.
Thomas QuinnInternational Health, School of Medicine, Johns Hopkins University, Baltimore Maryland, USA.
Hassan BrimDepartment of Pathology, Howard University Hospital, Washington, DC, USA.
Georgia DunstonDepartment of Microbiology, Howard University, Washington, DC, USA.
Howard University · US

Funding

STRUCTURAL/FUNCTIONAL CHARACTERIZATION OF AMINOGLYCOSIDEG12RR003048 · NCRR · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 1985 to 2011
$19.0M
Immunopathogenesis Of Chlamydia trachomatis InfectionZIAAI000358 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI QUINN, THOMAS · 2009 to 2022
$7.0M
NCRR NIH HHS G12 RR003048
6 · The paper itself

Abstract

aimTo examine the association of TLR4 Asp299Gly and MICA exon 5 microsatellites polymorphisms with severity of trachoma in a sub-Saharan East Africa population of Tanzanian villagers.

methodsThe samples were genotyped for MICA exon 5 microsatellites and the TLR4 299 A/G polymorphism by Restriction Fragment Length Polymorphism (RFLP), and GeneScan

resultsThe results showed an association between TLR4 and MICA polymorphisms and trachoma disease severity, as well as with protection. TLR4 an allele was significantly associated with inflammatory trachoma (p=0.0410), while the G allele (p=0.0410) was associated with protection.

conclusionTLR4 and MICA may modulate the risk of severity to trachoma disease by modulating the immune response to

Indexed as

Chlamydia trachomatisInflammationMajor histocompatibility complex (MHC) class I chain related gene AMICAMicrosatellite polymorphismSingle nucleotide polymorphismToll like receptor 4TrachomaTrichiasis

Identifiers

PMID27559544
PMCPMC4993598
OpenAlexW2463315461

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.