ReviewWorld journal of gastrointestinal oncology2016
Pancreatic injury in patients with septic shock: A literature review.
Review in World journal of gastrointestinal oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Acute Pancreatitis Associated With Anaphylactic Shock: A Case Report and Literature Review.Cureus · 2026Article
- Harnessing native corticosteroid-binding globulin to treat life-threatening septic shock.Endocrinology · 2026Article
- Decoding dynamic lipase trajectory patterns and in-hospital mortality in acute pancreatitis: insights from machine learning in intensive care units.European journal of medical research · 2025Article
- Pancreatic stone protein inhibits pyroptosis of pancreatic acinar cells in sepsis-associated pancreatic injury.Frontiers in medicine · 2025Article
- Non-pancreatic hyperlipasemia: A puzzling clinical entity.World journal of gastroenterology · 2024Observational
- A Successful Treatment of COVID-Induced Acute Idiopathic Pancreatitis with an RNA-Polymerase Inhibitor Agent.Cureus · 2024Article
- Screening and identification of the hub genes in severe acute pancreatitis and sepsis.Frontiers in molecular biosciences · 2024Article
- Multidetector CT Imaging Biomarkers as Predictors of Prognosis in Shock: Updates and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Pancreatic damage in COVID-19: Why? How?International journal of clinical practice · 2021Article
- A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.PloS one · 2021Article
- Hyperlipasemia in critically ill dogs with and without acute pancreatitis: Prevalence, underlying diseases, predictors, and outcome.Journal of veterinary internal medicine · 2020Article
- Shen fu injection for patients with septic shock: Protocol for an updated systematic review.Medicine · 2019Article
- Factors associated with increased pancreatic enzymes in septic patients: a prospective study.Journal of intensive care · 2017Article
- Nontraumatic Acute Elevation of Pancreatic Enzymes following Percutaneous Nephrolithotomy: A Rare Complication.Case reports in urology · 2017Article
- MiR-6835 promoted LPS-induced inflammation of HUVECs associated with the interaction between TLR-4 and AdipoR1 in lipid rafts.PloS one · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis and septic shock are life threatening condition associated with high mortality rate in critically-ill patients. This high mortality is mainly related to the inadequacy between oxygen delivery and cellular demand leading to the onset of multiorgan dysfunction. Whether this multiorgan failure affect the pancreas is not fully investigated. In fact, pancreatic injury may occur because of ischemia, overwhelming inflammatory response, oxidative stress, cellular apoptosis and/or metabolic derangement. Increased serum amylase and/or lipase levels are common in patients with septic shock. However, imaging test rarely reveal significant pancreatic damage. Whether pancreatic dysfunction does affect the prognosis of patients with septic shock or not is still a matter of debate. In fact, only few studies with limited sample size assessed the clinical relevance of the pancreatic injury in this group of patients. In this review, we aimed to describe the epidemiology and the physiopathology of pancreatic injury in septic shock patients, to clarify whether it requires specific management and to assess its prognostic value. Our main finding is that pancreatic injury does not significantly affect the outcome in septic shock patients. Hence, increased serum pancreatic enzymes without clinical features of acute pancreatitis do not require further imaging investigations and specific therapeutic intervention.
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