Evidence map›Paper›PMID 27559347›Full record

ArticleJournal of dentistry (Tehran, Iran)2015

Effect of Fluoxetine Consumption on Orthodontic Tooth Movement in Rats.

Amir Hossein Mirhashemi, Mohammad Sadegh Ahmad Akhoundi, Sedigheh Sheikhzadeh, Nafiseh Momeni, Ahmadreza Dehpour, Mojgan Alaeddini, Yasaman Kheirandish, Homa Farhadifard, Elahe Ansari

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of dentistry (Tehran, Iran), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study.Journal of dental research, dental clinics, dental prospects · 2020
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amir Hossein MirhashemiAssistant Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Orthodontic Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Sadegh Ahmad AkhoundiProfessor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Orthodontic Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Sedigheh SheikhzadehAssistant Professor, Orthodontic Department, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Nafiseh MomeniDentist, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ahmadreza DehpourProfessor, Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mojgan AlaeddiniAssociate Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Yasaman KheirandishAssistant Professor, Department of Oral and Maxillofacial Radiology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Homa FarhadifardPostgraduate Student, Orthodontic Department, Tehran University of Medical Sciences, Tehran, Iran.
Elahe AnsariDentist, Private Practice, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFluoxetine is a selective serotonin re-uptake inhibitor (SSRI) widely used for depression, bipolar disorder, anxiety and obsessive-compulsive disorder. The aim of this study was to assess the effect of fluoxetine on orthodontic tooth movement (OTM) in rats. MATERIALS AND

methodsForty-five male Wistar rats were randomly divided into three groups namely the control group (no medication), saline and fluoxetine dissolved in saline. In all groups, nickel titanium closed-coil spring was used between the left maxillary central incisor and first molar to exert 60g force at 2mm activation. Radiographs were taken at one and 21 days. After 21 days, the rats were sacrificed. The distance between the first and second molar teeth, optical density of bone, periodontal ligament (PDL) width, lacuna length and depth and number of osteoclasts were measured and compared among the groups.

resultsTooth movement significantly increased in the fluoxetine group (P=0.005). No significant differences were found in osteoclast count (P=0.069). The PDL width in the mesioapical region of root was significantly different among the groups (P=0.015). Statistical analysis did not show significant differences in depth or length of lacunae in any examined part of the root (P>0.05). Bone densitometry results showed that in fluoxetine group, density of bone in all four areas (alveolar bone, hard palate, skull and mandibular bone) significantly decreased from day one to day 21 (P< 0.05).

conclusionThis study indicated that fluoxetine decreased bone density, which resulted in subsequently greater tooth movement in rats; however, further studies are needed on humans.

Indexed as

FluoxetineRatsTooth Movement

Identifiers

PMID27559347
PMCPMC4983303

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.