ArticleFrontiers in plant science2016
Genome-Wide Comparative Analyses Reveal the Dynamic Evolution of Nucleotide-Binding Leucine-Rich Repeat Gene Family among Solanaceae Plants.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 109 citations in OpenAlex.
- Article
- Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026Review
- Comparative analysis of PRR receptors and R genes reveals structural and functional divergence between wild, ancestral, and commercial citrus species.BMC genomics · 2026Article
- Molecular Evolution of the NLR Gene Family Reveals Diverse Innate Immune Strategies in Bats.Biomolecules · 2025Article
- RNA silencing: the future potential strategy for engineering virus resistance in plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- Identification of a gene conferring broad-spectrum orthotospovirus resistance in Solanaceae.Science advances · 2025Article
- Tracing the path from conservation to expansion evolutionary insights into NLR genes in oleaceae.BMC plant biology · 2025Article
- The gap-free assembly of pepper genome reveals transposable-element-driven expansion and rapid evolution of pericentromeres.Plant communications · 2025Article
- Article
- Resistify: A Novel NLR Classifier That Reveals Helitron-Associated NLR Expansion in Solanaceae.Bioinformatics and biology insights · 2025Article
- Comparative analysis of the NLR gene family in the genomes of garden asparagus (Frontiers in plant science · 2025Article
- Comprehensive Genome-Wide Analysis of the Receptor-like Protein Gene Family and Functional Analysis ofPlants (Basel, Switzerland) · 2024Article
- The landscape of sequence variations between resistant and susceptible hot peppers to predict functional candidate genes against bacterial wilt disease.BMC plant biology · 2024Article
- Activation of an atypical plant NLR with an N-terminal deletion initiates cell death at the vacuole.EMBO reports · 2024Article
- NRC Immune receptor networks show diversified hierarchical genetic architecture across plant lineages.The Plant cell · 2024Article
- Conifers Concentrate Large Numbers of NLR Immune Receptor Genes on One Chromosome.Genome biology and evolution · 2024Article
- Comparative analysis, diversification, and functional validation of plant nucleotide-binding site domain genes.Scientific reports · 2024Article
- Coping with alpine habitats: genomic insights into the adaptation strategies ofHorticulture research · 2024Article
- Genome-wide identification and characterization of NBLRR genes in finger millet (Eleusine coracana L.) and their expression in response to Magnaporthe grisea infection.BMC plant biology · 2024Article
- Divergent evolution ofFrontiers in plant science · 2024Article
1 more citing papers are in PubMed but not listed here.
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Plants have evolved an elaborate innate immune system against invading pathogens. Within this system, intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptors are known play critical roles in effector-triggered immunity (ETI) plant defense. We performed genome-wide identification and classification of NLR-coding sequences from the genomes of pepper, tomato, and potato using fixed criteria. We then compared genomic duplication and evolution features. We identified intact 267, 443, and 755 NLR-encoding genes in tomato, potato, and pepper genomes, respectively. Phylogenetic analysis and classification of Solanaceae NLRs revealed that the majority of NLR super family members fell into 14 subgroups, including a TIR-NLR (TNL) subgroup and 13 non-TNL subgroups. Specific subgroups have expanded in each genome, with the expansion in pepper showing subgroup-specific physical clusters. Comparative analysis of duplications showed distinct duplication patterns within pepper and among Solanaceae plants suggesting subgroup- or species-specific gene duplication events after speciation, resulting in divergent evolution. Taken together, genome-wide analysis of NLR family members provide insights into their evolutionary history in Solanaceae. These findings also provide important foundational knowledge for understanding NLR evolution and will empower broader characterization of disease resistance genes to be used for crop breeding.
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